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Establishing a Severe Corneal Inflammation Model in Rats Based on Corneal Epithelium Curettage Combined with Corneal Sutures
Published on: November 22, 2024
Corneal ulceration and episcleritis associated with Wiskott-Aldrich syndrome
Bruce M Zagelbaum1, Danielle C Kalberer2, Barry S Pinchoff1
1Department of Ophthalmology, Hofstra Northwell School of Medicine, 500 Hofstra Blvd, Hempstead, NY 11549, United States.
Purpose:
To present anterior segment ophthalmic manifestations of Wiskott-Aldrich syndrome (WAS), a rare X-linked primary immune-deficiency.
Observations:
A 15-year old male with WAS presented with multiple corneal ulcers of the left eye. Once resolved, this was followed by separate episodes of episcleritis in the left eye and corneal infiltrates of the right eye. Successful treatment included topical antibiotics and anti-inflammatories.
Conclusions:
Ocular manifestations of WAS, due to secondary infection and inflammation, may be severe. This case report emphasizes the importance of prompt ophthalmic evaluation and treatment of these patients.
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