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A response adaptive design for ordinal categorical responses
Atanu Biswas1, Rahul Bhattacharya2, Soumyadeep Das2
1a Applied Statistics Unit , Indian Statistical Institute , Kolkata , India.
Abstract:
A two treatment response adaptive design is developed for phase III clinical trials with ordinal categorical treatment outcome using Goodman-Kruskal measure of association. Properties of the proposed design are studied both empirically and theoretically and the acceptability is further illustrated using two real data-sets; one from a clinical trial with trauma patients and the other from a trial with patients having rheumatoid arthritis.
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