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[Cardionatrin, a cardiac hormone].

A Fournier, A De Bold

    Presse Medicale (Paris, France : 1983)
    |February 28, 1987
    PubMed
    Summary

    Atrial natriuretic factor (ANF), also known as cardionatrin, was discovered in 1981. This hormone plays a key role in cardiovascular homeostasis by lowering blood pressure and promoting natriuresis.

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    Neuropeptide Y inhibits alpha-MSH release from rat hypothalamic slices through a pertussis toxin-sensitive G protein.

    Brain research·1992

    Area of Science:

    • Endocrinology
    • Cardiovascular Physiology
    • Molecular Biology

    Context:

    • The discovery of atrial extracts' hypotensive and natriuretic effects in 1981.
    • Identification and biosynthesis of atrial natriuretic factor (ANF) or cardionatrin.
    • Understanding the role of atrial granules in hormone storage.

    Purpose:

    • To elucidate the role of ANF in cardiovascular homeostasis.
    • To identify ANF as a key hormone in regulating blood pressure and fluid balance.
    • To explore the mechanisms by which ANF exerts its effects.

    Summary:

    • Atrial natriuretic factor (ANF), or cardionatrin, is a hormone synthesized and stored in atrial granules.
    • ANF secretion is stimulated by atrial distension, highlighting its role in cardiovascular homeostasis.
    • ANF antagonizes the renin-angiotensin-aldosterone and adrenergic systems, reducing blood pressure.
    • Its action involves stimulating receptors that modulate cyclic guanosine monophosphate and cyclic adenosine monophosphate levels.
    • The natriuretic effect is attributed to increased glomerular filtration rate and papillar interstitial fluid secretion.

    Impact:

    • Discovery of a novel hormone involved in blood pressure regulation.
    • Understanding the molecular mechanisms of cardiovascular homeostasis.
    • Potential therapeutic targets for hypertension and fluid balance disorders.

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