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Repeat patient testing-based quality control (RPT-QC) offers a cost-effective, species-specific alternative to commercial controls for veterinary labs. Its performance is comparable to commercial quality control materials (QCM) for most tests.

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Area of Science:

  • Veterinary Hematology
  • Laboratory Quality Control
  • Diagnostic Accuracy

Background:

  • Repeat patient testing-based quality control (RPT-QC) is explored as a cost-effective quality control method for veterinary laboratories.
  • It is particularly relevant for labs with limited budgets for commercial control material (QCM) or those prioritizing species-specific matrices.

Purpose of the Study:

  • To evaluate if RPT-QC can achieve total error (TEa), probability of error detection (Ped), and probability of false rejection (Pfr) comparable to commercial QCM.
  • To assess the performance of RPT-QC on Advia 120 and scil Vet ABC hematology analyzers.

Main Methods:

  • Control limits for WBC, RBC, HGB, HCT, MCV, and PLT were calculated using routine canine specimens on two analyzers.
  • Specimens were re-tested after 24 hours to establish RPT-QC limits, which were then validated.
  • Achievable TEa, Ped, and Pfr were analyzed using Westgard EZRules3 and compared to commercial QCM.

Main Results:

  • Theoretical performance of RPT-QC was similar to commercial QCM-QC for most parameters and instruments.
  • Achievable TEa values for RPT-QC closely aligned with ASVCP recommendations, with minor exceptions for PLT and WBC.

Conclusions:

  • RPT-QC offers advantages including a species-specific matrix, low cost, and no material deterioration.
  • Challenges include daily access to normal canine specimens and subjective control limit determination.
  • Further research is needed to confirm RPT-QC performance and explore its use with abnormal specimens.