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Updated: Feb 13, 2026

Closure of a Patent Foramen Ovale PFO: An Intervention Sequence
Published on: December 23, 2022
Transcatheters for closure of patent foramen ovales
Gianluca Rigatelli1, Marco Zuin2,3
1a Cardiovascular Diagnosis and Endoluminal Interventions , Rovigo General Hospital , Rovigo , Italy.
Introduction:
Nowadays patent foramen ovale (PFO) closure is considered clinically beneficial and even cost-effective over medical therapy in secondary prevention of stroke due to paradoxical embolism.
Areas Covered:
In this review, the authors discuss both anatomical and technical details and constructive concepts of current devices used for PFO closure.
Expert Commentary:
Right atrial and interatrial septum anatomy is more complex than usually thought and a unique prosthesis that fits properly to all the possible morphologies is far from being designed. Existing devices can be classified into suture-like devices, metal disk occluders and mixed metal/tissue occluders depending on the mechanism of closure and the amount of metal/tissue components. Moreover, during recent years, nothing-behind technology has been introduced and will be closely watched as a future option.
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