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Updated: Feb 13, 2026

Examining Recall Memory in Infancy and Early Childhood Using the Elicited Imitation Paradigm
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Stony Hard Skin During Early Infancy.

Julien Bachour1, Fatmeh Ghandour, Alfred Ammoury

  • 1Saint George Hospital University Medical Center, University of Balamand, Beirut, Lebanon.

The American Journal of Dermatopathology
|March 6, 2018
PubMed
Summary

Stiff skin syndrome, a rare childhood disease, causes stony hard skin. This case highlights adipocyte entrapment as a potentially key, unrecognized diagnostic finding.

Area of Science:

  • Dermatology
  • Pathology
  • Rare Diseases

Background:

  • Stiff skin syndrome (SSS) is a rare genetic disorder characterized by woody, indurated skin.
  • Typically presenting in early childhood, SSS poses diagnostic challenges due to its rarity.

Observation:

  • A 12-year-old boy presented with clinical features suggestive of stiff skin syndrome.
  • Skin biopsy was performed to investigate the underlying pathology.

Findings:

  • Histopathological examination of the biopsy revealed significant adipocyte entrapment within the dermal collagen.
  • Adipocyte entrapment is proposed as a novel and critical diagnostic marker for stiff skin syndrome.

Implications:

  • Identifying adipocyte entrapment could improve the diagnostic accuracy and speed for stiff skin syndrome.

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  • This finding may open new avenues for understanding the pathophysiology of SSS.
  • Further research is warranted to validate adipocyte entrapment as a consistent pathological feature of SSS.