A reference interval for serum IgG subclasses in Chinese children
Zhongjuan Liu1, Chuiwen Deng2,3, Ping Li2,3
1Department of Clinical Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Insights
This study establishes crucial reference intervals for serum immunoglobulin G (IgG) subclasses in Chinese children. These findings are vital for accurate laboratory interpretation and clinical decision-making in pediatric healthcare.
Area of Science:
- Clinical immunology
- Pediatric laboratory medicine
Background:
- Serum immunoglobulin G (IgG) subclass reference intervals (RIs) exhibit significant geographical variations.
- Establishing accurate RIs for specific populations is essential for reliable clinical interpretation.
Purpose of the Study:
- To determine and establish reference intervals for serum IgG subclasses in a cohort of Chinese children.
- To provide essential data for accurate diagnosis and treatment of immunological disorders in this demographic.
Main Methods:
- Study conducted following International Federation of Clinical Chemistry and Clinical and Laboratory Standards Institute guidelines.
- Serum IgG subclass levels measured in 607 apparently healthy Chinese children.
- Data stratified by age groups to establish age-specific RIs through statistical analysis.
Main Results:
- Median RIs for IgG subclasses (IgG1, IgG2, IgG3, IgG4) were determined across various pediatric age groups (1 month to 16 years).
- Specific median values provided for each subclass and age bracket, highlighting developmental changes.
- Example: IgG1 ranged from 2.78 g/L (1-6 months) to 7.45 g/L (13-16 years).
Conclusions:
- This study presents the first established reference intervals for serum IgG subclasses specifically for Chinese children.
- The findings are critical for improving the accuracy of laboratory diagnostics and clinical management of pediatric patients in China.
Background:
Reference intervals (RIs) for serum IgG subclasses vary greatly among different geographical regions. The present study aimed to establish RIs for serum IgG subclasses in Chinese children, which is essential for interpretation of laboratory findings and making clinical decisions.
Methods:
This study was performed in accordance with guideline C28-A3, proposed by the International Federation of Clinical Chemistry and the Clinical and Laboratory Standards Institute. In total, 607 apparently healthy Chinese children were enrolled, and serum levels of IgG subclasses were measured. Individuals were stratified by age and the RIs were determined through statistical analysis.
Results:
Following were the median values of RIs for serum IgG subclasses in Chinese children: IgG1, 2.78 g/L; IgG2, 0.85 g/L; IgG3, 0.13 g/L; IgG4, 0.06 g/L at 1-6 months of age; IgG1, 3.64 g/L; IgG2, 0.73 g/L; IgG3, 0.19 g/L; IgG4, 0.03 g/L at 6-12 months of age; IgG1, 5.15 g/L; IgG2, 0.87 g/L; IgG3, 0.19 g/L; IgG4, 0.07 g/L at 1-2 years of age; IgG1, 5.26 g/L; IgG2, 1.23 g/L; IgG3, 0.14 g/L; IgG4, 0.11 g/L at 2-3 years of age; IgG1, 6.33 g/L; IgG2, 1.8 g/L; IgG3, 0.2 g/L; IgG4, 0.21 g/L at age 3-4 years; IgG1, 7.05 g/L; IgG2, 1.87 g/L; IgG3, 0.25 g/L; IgG4, 0.29 g/L at 4-6 years of age; IgG1, 6.19 g/L; IgG2, 1.93 g/L; IgG3, 0.2 g/L; IgG4, 0.28 g/L at 6-9 years of age; IgG1, 6.76 g/L; IgG2, 2.29 g/L; IgG3, 0.27 g/L; IgG4, 0.37 g/L at 10-12 years of age; IgG1, 7.45 g/L; IgG2, 2.92 g/L; IgG3, 0.28 g/L; IgG4, 0.38 g/L at 13-16 years of age.
Conclusion:
To our knowledge, this study is the first to establish RIs for serum IgG subclasses exclusively in Chinese children.
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