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Second-harmonic imaging microscopy for identifying colorectal intraepithelial neoplasia
L H Li1, W Z Jiang2, D Y Kang3
1Key Laboratory of OptoElectronic Science and Technology for Medicine of Ministry of Education, Fujian Provincial Key Laboratory for Photonics Technology, Fujian Normal University, Fuzhou, Fujian, China.
Journal of Microscopy
|March 6, 2018
Summary
Second-harmonic imaging microscopy visualizes precancerous colorectal lesion changes. This label-free technique distinguishes normal from diseased tissues, aiding early diagnosis and treatment of colorectal diseases.
Area of Science:
- Biomedical Optics
- Gastroenterology
- Pathology
Background:
- Colorectal diseases, including precancerous lesions, require early detection for effective treatment.
- Current diagnostic methods may have limitations in real-time tissue analysis.
Purpose of the Study:
- To evaluate the potential of second-harmonic imaging microscopy for monitoring precancerous colorectal lesions.
- To identify morphologic changes associated with colorectal disease progression.
Main Methods:
- Second-harmonic imaging microscopy was employed to visualize colorectal tissues at various stages of disease.
- Morphologic variables of glands and lamina propria collagen were quantified.
Main Results:
- Significant changes in gland and lamina propria morphology were observed with disease progression.
- The microscopy enabled direct visualization of warning symptoms in precancerous lesions.
- Quantification of morphologic variables correlated with disease development.
Conclusions:
- Second-harmonic imaging microscopy offers a label-free method for distinguishing normal from precancerous colorectal tissues.
- This technique shows promise for the early diagnosis and treatment of colorectal diseases.
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