Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Solubility of Ionic Compounds02:55

Solubility of Ionic Compounds

68.3K
Solubility is the measure of the maximum amount of solute that can be dissolved in a given quantity of solvent at a given temperature and pressure. Solubility is usually measured in molarity (M) or moles per liter (mol/L). A compound is termed soluble if it dissolves in water.
68.3K
Insulin Formulations: Types and Delivery01:27

Insulin Formulations: Types and Delivery

797
Insulin preparations are categorized by their duration of action into short-acting and long-acting types. Two strategies are used to modify insulin's absorption and pharmacokinetic profile: slowing the absorption post-subcutaneous injection, or altering human insulin's amino acid sequence or protein structure. These changes retain the insulin's ability to bind to the insulin receptor, but alter its behavior in solution or after injection.
Short-acting insulins are divided into...
797
Factors Affecting Solubility04:01

Factors Affecting Solubility

37.3K
Compared with pure water, the solubility of an ionic compound is less in aqueous solutions containing a common ion (one also produced by dissolution of the ionic compound). This is an example of a phenomenon known as the common ion effect, which is a consequence of the law of mass action that may be explained using Le Chȃtelier’s principle. Consider the dissolution of silver iodide:
37.3K
Solubility Equilibria03:07

Solubility Equilibria

57.9K
Solubility equilibria are established when the dissolution and precipitation of a solute species occur at equal rates. These equilibria underlie many natural and technological processes, ranging from tooth decay to water purification. An understanding of the factors affecting compound solubility is, therefore, essential to the effective management of these processes. This section applies previously introduced equilibrium concepts and tools to systems involving dissolution and precipitation.
The...
57.9K
Physical Properties Affecting Solubility02:19

Physical Properties Affecting Solubility

27.4K
Solutions of Gases in Liquids
As for any solution, the solubility of a gas in a liquid is affected by the attractive intermolecular forces between solute and solvent species. Unlike solid and liquid solutes, however, there is no solute-solute intermolecular attraction to overcome when a gaseous solute dissolves in a liquid solvent since the atoms or molecules comprising a gas are far separated and experience negligible interactions. Consequently, solute-solvent interactions are the sole...
27.4K
Bioavailability Study Design: Single Versus Multiple Dose Studies01:11

Bioavailability Study Design: Single Versus Multiple Dose Studies

253
Bioavailability studies are essential for understanding how a drug is absorbed, distributed, metabolized, and excreted in the body. These studies assess the extent and rate at which the active pharmaceutical agent becomes available at the site of action. The design of bioavailability studies can involve single-dose or multiple-dose regimens, each with distinct advantages and limitations.Single-dose studies are the preferred approach due to their simplicity and reduced drug exposure for...
253

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Understanding the molecular insights of marketed liposomal drugs using molecular dynamics simulations of reduced scale coarse-grained models.

npj drug discovery·2026
Same author

Discovery of a New Scaffold RSK2 Inhibitor With Virtual and Phenotypical Screening.

ChemMedChem·2026
Same author

Machine learning algorithms to predict spray dried protein/peptide formulations.

International journal of pharmaceutics·2026
Same author

Lipid droplets-mediated delivery of curcumin for targeted mitochondrial photodynamic therapy.

International journal of pharmaceutics: X·2026
Same author

DeepCYP: an integrated deep learning web server for the holistic "pathway-site product" prediction of CYP450 metabolism.

Nucleic acids research·2026
Same author

Computational insights into drug hygroscopicity by coupling machine learning and molecular simulation.

Drug delivery and translational research·2026

Related Experiment Video

Updated: Feb 13, 2026

Formulating and Characterizing Lipid Nanoparticles for Gene Delivery using a Microfluidic Mixing Platform
09:41

Formulating and Characterizing Lipid Nanoparticles for Gene Delivery using a Microfluidic Mixing Platform

Published on: February 25, 2021

25.4K

Computer-Aided Formulation Design for a Highly Soluble Lutein-Cyclodextrin Multiple-Component Delivery System.

Qianqian Zhao1, Nikhila Miriyala2, Yan Su1

  • 1State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences (ICMS) , University of Macau , Macau , China.

Molecular Pharmaceutics
|March 6, 2018
PubMed
Summary

This study developed a highly soluble lutein-cyclodextrin multiple-component delivery system (lutein-CD-MCDS) using modeling and experiments. The novel formulation significantly enhanced lutein solubility and bioavailability.

Keywords:
bioavailabilitycomputer-aided formulation designcyclodextrinluteinmolecular dynamics simulationmultiple-component system

More Related Videos

Formulation and Characterization of Bioactive Agent Containing Nanodisks
07:58

Formulation and Characterization of Bioactive Agent Containing Nanodisks

Published on: March 17, 2023

1.7K
Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study
10:10

Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study

Published on: August 15, 2016

10.8K

Related Experiment Videos

Last Updated: Feb 13, 2026

Formulating and Characterizing Lipid Nanoparticles for Gene Delivery using a Microfluidic Mixing Platform
09:41

Formulating and Characterizing Lipid Nanoparticles for Gene Delivery using a Microfluidic Mixing Platform

Published on: February 25, 2021

25.4K
Formulation and Characterization of Bioactive Agent Containing Nanodisks
07:58

Formulation and Characterization of Bioactive Agent Containing Nanodisks

Published on: March 17, 2023

1.7K
Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study
10:10

Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study

Published on: August 15, 2016

10.8K

Area of Science:

  • Pharmaceutical Science
  • Materials Science
  • Computational Chemistry

Background:

  • Cyclodextrin complexation is a key strategy for enhancing drug solubility.
  • Lutein, a poorly soluble carotenoid, benefits from improved delivery systems for pharmaceutical applications.

Purpose of the Study:

  • To develop a highly soluble lutein-cyclodextrin multiple-component delivery system (lutein-CD-MCDS).
  • To enhance lutein solubility, dissolution rate, stability, and bioavailability using combined modeling and experimental approaches.

Main Methods:

  • Phase solubility diagrams and molecular dynamics (MD) simulations were used to study lutein-cyclodextrin interactions.
  • Formulation screening identified optimal components for the lutein-CD-MCDS.
  • Characterization involved in vitro dissolution, DSC, FT-IR, SEM, and PXRD.
  • Caco-2 cell uptake and in vivo bioavailability studies were conducted.

Main Results:

  • Lutein-cyclodextrin binary systems showed weak interactions and insignificant solubility improvement.
  • The developed lutein-CD-MCDS achieved over 400-fold solubility improvement.
  • MD simulations revealed auxiliary polymers (TWEEN 80, poloxamer 188) facilitated bridged interactions, enhancing solubility, dissolution, and stability.
  • Lutein-CD-MCDS demonstrated significantly higher Caco-2 cell uptake and a 6.6-fold increase in relative bioavailability compared to pure lutein.

Conclusions:

  • A highly soluble lutein-CD-MCDS was successfully developed using a combined computational and experimental approach.
  • The formulation significantly improved lutein's solubility, dissolution, stability, and bioavailability.
  • Computer-aided formulation design presents a promising strategy for developing advanced drug delivery systems.