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Related Concept Videos

Gene Therapy00:59

Gene Therapy

27.7K
Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
27.7K
Group Therapy01:26

Group Therapy

469
Group therapy is a sociocultural approach to psychological treatment, where individuals with shared psychological challenges come together under the guidance of a mental health professional. This therapeutic modality offers unique opportunities for individuals to connect, share, and grow within the context of a supportive group. By fostering mutual understanding and collaboration, group therapy can address a range of psychological concerns effectively, often complementing or surpassing the...
469
Gene Flow02:39

Gene Flow

38.1K
Gene flow is the transfer of genes among populations, resulting from either the dispersal of gametes or from the migration of individuals.
38.1K
Gene Families01:57

Gene Families

10.0K
Gene families consist of groups of genes proposed to have originated from a common ancestor. Typically these arise through events in which a gene or genes are mistakenly duplicated during cell division. Unlike their parent genes (which are subject to selection pressure to maintain function), these gene copies do not need to preserve their sequences and may evolve at a relatively faster rate.
Occasionally these regions can be adapted to take on new roles within the organism, becoming novel genes...
10.0K
Gene Conversion02:08

Gene Conversion

10.7K
Other than maintaining genome stability via DNA repair, homologous recombination plays an important role in diversifying the genome. In fact, the recombination of sequences forms the molecular basis of genomic evolution. Random and non-random permutations of genomic sequences create a library of new amalgamated sequences. These newly formed genomes can determine the fitness and survival of cells. In bacteria, homologous and non-homologous types of recombination lead to the evolution of new...
10.7K
What is Gene Expression?01:42

What is Gene Expression?

197.1K
Overview
Gene expression is the process in which DNA directs the synthesis of functional products, that is, proteins. Cells can regulate gene expression at various stages. It allows organisms to generate different cell types and enables cells to adapt to internal and external factors.
Genetic Information Flows from DNA to RNA to Protein
A gene is a stretch of DNA that serves as the blueprint for functional RNAs and proteins. Since DNA is made up of nucleotides and proteins consist of amino...
197.1K

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Related Experiment Video

Updated: Feb 13, 2026

Ultrahigh Resolution Mouse Optical Coherence Tomography to Aid Intraocular Injection in Retinal Gene Therapy Research
10:10

Ultrahigh Resolution Mouse Optical Coherence Tomography to Aid Intraocular Injection in Retinal Gene Therapy Research

Published on: November 2, 2018

9.9K

Retinal gene therapy.

Neruban Kumaran1, Michel Michaelides1, Alexander J Smith1

  • 1NIHR Biomedical Research Centre for Ophthalmology at Moofields Eye Hospital and UCL, 162 City Road, London, UK.

British Medical Bulletin
|March 6, 2018
PubMed
Summary
This summary is machine-generated.

Gene therapy shows promise for inherited retinal diseases like RPE65-associated Leber Congenital Amaurosis (RPE65-LCA), but vision improvement can be limited by retinal degeneration.

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Limbal Approach-Subretinal Injection of Viral Vectors for Gene Therapy in Mice Retinal Pigment Epithelium
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Preparation of Mouse Retinal Cryo-sections for Immunohistochemistry
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Preparation of Mouse Retinal Cryo-sections for Immunohistochemistry

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Limbal Approach-Subretinal Injection of Viral Vectors for Gene Therapy in Mice Retinal Pigment Epithelium
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Preparation of Mouse Retinal Cryo-sections for Immunohistochemistry
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Area of Science:

  • Ophthalmology
  • Genetics
  • Medical Research

Background:

  • Inherited retinal diseases are a primary cause of vision impairment.
  • Gene therapy presents a potential therapeutic avenue for these conditions.

Purpose of the Study:

  • To review the current state of gene therapy for inherited retinal diseases.
  • To identify areas of agreement, controversy, and future research directions.

Main Methods:

  • Literature review of gene therapy trials for retinal diseases.
  • Analysis of data from Pubmed and clinicaltrials.gov.

Main Results:

  • Gene therapy can improve vision in RPE65-LCA, but benefits are limited by retinal degeneration.
  • The magnitude and durability of vision improvement remain areas of controversy.

Conclusions:

  • Gene therapy for inherited retinal diseases is rapidly evolving.
  • Advancements in vector technology and trial design are crucial for future success.