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Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors
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Tearing down the walls: FDA approves next generation sequencing (NGS) assays for actionable cancer genomic

Matteo Allegretti1,2, Alessandra Fabi2,3, Simonetta Buglioni2,4

  • 1Oncogenomics and Epigenetics, IRCSS Regina Elena National Cancer Institute, Rome, Italy.

Journal of Experimental & Clinical Cancer Research : CR
|March 7, 2018
PubMed

Insights

The US FDA approved Next Generation Sequencing (NGS) panels for cancer care, marking a new standard. This advances precision oncology by integrating diverse biological and clinical fields.

Area of Science:

  • Oncology
  • Genomics
  • Bioinformatics

Background:

  • The US Food and Drug Administration (FDA) approved two Next Generation Sequencing (NGS) panels for clinical use.
  • These panels identify actionable genomic aberrations in cancer patients.
  • This marks the first regulatory endorsement of NGS as a standard of care in oncology.

Discussion:

  • The approval signifies a paradigm shift in cancer diagnostics and treatment.
  • It bridges the gap between system biology and clinical practice.
  • It integrates research, diagnosis, prevention, and therapy in oncology.

Key Insights:

  • NGS panel approval facilitates precision medicine by identifying specific genetic mutations.
  • This regulatory milestone integrates computational biology with empirical therapy assignment.
  • The approval breaks down conceptual silos in cancer research and clinical application.

Outlook:

  • This advancement is expected to accelerate the adoption of genomic profiling in routine cancer care.
  • It paves the way for more personalized and effective cancer treatments.
  • Future research will likely focus on expanding the utility of NGS in diverse cancer types and patient populations.
Keywords:
BioinformaticsCancer screening and preventionEthicsGenomic aberrationsNext generation sequencing (NGS)Patient advocacyPrecision medicineRegulatory issues

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