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Updated: Feb 13, 2026

Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up
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Exploring Stem Cell Heterogeneity in Chronic Myeloid Leukemia

Chinmay Munje1, Mhairi Copland1

  • 1Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Bearsden G61 1QH, UK.

Trends in Cancer
|March 7, 2018
PubMed

Until very recently, understanding the complexity of the stem cell (SC) compartment in both normal and leukemic hematopoiesis has been challenging due to the inability to separate and study normal and leukemic SCs at the single-cell level. Recent advances in cell-sorting techniques and single-cell technologies now make this possible, with the identification of a population of highly quiescent chronic myeloid leukemia (CML) SCs that is enriched following therapy with tyrosine kinase inhibitors (TKIs).

Keywords:
chronic myeloid leukemiahematopoietic stem cellheterogeneityleukemic stem cellsingle-cell transcriptomics

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