Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Replicative Cell Senescence02:15

Replicative Cell Senescence

4.4K
Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds...
4.4K
Cancer02:18

Cancer

54.6K
Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
54.6K
What is Cancer?02:12

What is Cancer?

14.5K
Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of...
14.5K
Cancer Prevention02:59

Cancer Prevention

8.2K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
8.2K
Cancer Vaccines01:30

Cancer Vaccines

1.1K
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
1.1K
Skin Cancer01:30

Skin Cancer

6.0K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
6.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

When effective anticancer therapies are, in fact, destabilizing the tumor's Group Phenotypic Composition.

NPJ precision oncology·2026
Same author

Spatiotemporal dynamics, risk assessment, and trophic fate of pharmaceuticals in a rurally-zoned freshwater terminal lake.

Journal of hazardous materials·2026
Same author

Symbiont Reintroduction Alters Tumor Progression and Life-History Traits in the Tumor-Bearing Freshwater Cnidarian <i>Hydra oligactis</i>.

Ecology and evolution·2026
Same author

Selection for Function in Early Life: Implications for Early-Onset Pathologies.

Evolutionary applications·2026
Same author

Dengue virus harnesses mosquito Syntenin to load and secrete viral RNA into salivary exosomes.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Selection for Function in Complex Distributed Pathological Systems.

Evolutionary applications·2026

Related Experiment Video

Updated: Feb 13, 2026

A Sensitive Method to Quantify Senescent Cancer Cells
09:18

A Sensitive Method to Quantify Senescent Cancer Cells

Published on: August 2, 2013

21.3K

Cancer Is Not (Only) a Senescence Problem.

Frédéric Thomas1, Fabrice Vavre2, Tazzio Tissot3

  • 1CREEC/MIVEGEC, UMR IRD/CNRS/UM 5290, 911 Avenue Agropolis, BP 64501, 34394 Montpellier Cedex 5, France.

Trends in Cancer
|March 7, 2018
PubMed
Summary

Cancer is often seen as age-related, but it significantly impacts organisms early in life, acting as a major evolutionary force. Understanding these early, subclinical effects is crucial for a complete view of malignant diseases.

More Related Videos

A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence
13:59

A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence

Published on: August 12, 2018

8.6K
Far-Red Fluorescent Senescence-Associated &#946;-Galactosidase Probe for Identification and Enrichment of Senescent Tumor Cells by Flow Cytometry
14:01

Far-Red Fluorescent Senescence-Associated β-Galactosidase Probe for Identification and Enrichment of Senescent Tumor Cells by Flow Cytometry

Published on: September 13, 2022

5.8K

Related Experiment Videos

Last Updated: Feb 13, 2026

A Sensitive Method to Quantify Senescent Cancer Cells
09:18

A Sensitive Method to Quantify Senescent Cancer Cells

Published on: August 2, 2013

21.3K
A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence
13:59

A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence

Published on: August 12, 2018

8.6K
Far-Red Fluorescent Senescence-Associated &#946;-Galactosidase Probe for Identification and Enrichment of Senescent Tumor Cells by Flow Cytometry
14:01

Far-Red Fluorescent Senescence-Associated β-Galactosidase Probe for Identification and Enrichment of Senescent Tumor Cells by Flow Cytometry

Published on: September 13, 2022

5.8K

Area of Science:

  • Evolutionary biology
  • Cancer research
  • Gerontology

Background:

  • Cancer is predominantly viewed as a disease of aging and senescence.
  • Subclinical cancer exists in many species, but its early-life impacts are poorly understood.
  • Malignant pathologies are often considered only in their fatal, late-stage manifestations.

Purpose of the Study:

  • To propose a novel perspective on cancer as an early-life selective force.
  • To highlight the significance of subclinical cancer's influence on organismal ecology and evolution.
  • To encourage research into the pre-fatal effects of oncogenic phenomena.

Main Methods:

  • Conceptual review and theoretical argument.
  • Synthesis of existing knowledge on cancer, aging, and evolution.
  • Comparative analysis of cancer's role across different life stages.

Main Results:

  • Cancer exerts a significant, yet overlooked, burden on organisms from early in life.
  • Malignant processes likely act as a potent selective pressure throughout an organism's lifespan.
  • Early-stage cancer influences organismal fitness and evolutionary trajectories before clinical detection.

Conclusions:

  • A paradigm shift is needed to view cancer as an integral factor in early life and evolution.
  • Investigating subclinical cancer is essential for a comprehensive understanding of its biological and ecological impact.
  • This new perspective can enhance our knowledge of how oncogenic phenomena shape animal populations over time.