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Published on: February 21, 2025
Coagulopathy induced by traumatic brain injury: systemic manifestation of a localized injury
Jianning Zhang1,2, Fangyi Zhang3, Jing-Fei Dong4,5
1Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, China.
Abstract:
Traumatic brain injury (TBI)-induced coagulopathy is a common and well-recognized risk for poor clinical outcomes, but its pathogenesis remains poorly understood, and treatment options are limited and ineffective. We discuss the recent progress and knowledge gaps in understanding this lethal complication of TBI. We focus on (1) the disruption of the brain-blood barrier to disseminate brain injury systemically by releasing brain-derived molecules into the circulation and (2) TBI-induced hypercoagulable and hyperfibrinolytic states that result in persistent and delayed intracranial hemorrhage and systemic bleeding.
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