Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Covalently Linked Protein Regulators02:04

Covalently Linked Protein Regulators

9.7K
Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an important role in the function and stability of these proteins. Covalently linked molecules include functional groups, such as methyl, acetyl, and phosphate groups, and also small proteins, such as ubiquitin. There are around 200 different types of covalent regulators that have been identified.
These groups modify specific amino acids in a protein....
9.7K
Imaging Studies VII: Vascular Imaging01:19

Imaging Studies VII: Vascular Imaging

389
DefinitionRenal angiography, also known as renal arteriography, is an imaging technique used to obtain a comprehensive view of blood flow and the vascular structure of blood vessels in the kidneys and surrounding areas.PurposeRenal angiography detects blood vessel abnormalities in the kidneys, such as aneurysms, stenosis, thrombosis, vascular tumors, and renal artery stenosis. It evaluates kidney function and guides interventional treatments like angioplasty or stent placement.Pre-Procedure...
389
X-linked Traits01:19

X-linked Traits

58.9K
In most mammalian species, females have two X sex chromosomes and males have an X and Y. As a result, mutations on the X chromosome in females may be masked by the presence of a normal allele on the second X. In contrast, a mutation on the X chromosome in males more often causes observable biological defects, as there is no normal X to compensate. Trait variations arising from mutations on the X chromosome are called “X-linked”.
58.9K
X-ray Imaging01:24

X-ray Imaging

10.6K
German physicist Wilhelm Röntgen (1845–1923) was experimenting with electrical current when he discovered that a mysterious and invisible "ray" would pass through his flesh but leave an outline of his bones on a screen coated with a metal compound. In 1895, Röntgen made the first durable record of the internal parts of a living human: an "X-ray" image (as it came to be called) of his wife’s hand. Scientists worldwide quickly began their own experiments with...
10.6K
Brain Imaging01:14

Brain Imaging

760
Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
760
Imaging Studies IV: Magnetic Resonance Imaging01:27

Imaging Studies IV: Magnetic Resonance Imaging

285
Introduction:Magnetic Resonance Imaging, or MRI, can include a specialized imaging technique of the urinary system known as Magnetic Resonance Urography (MRU). This radiation-free technique uses strong magnetic fields and radio waves to produce detailed images with the help of a computer. MRU is particularly effective for visualizing fluid-filled structures like the kidneys, ureters, and bladder.Applications of MRI in the Genitourinary SystemKidneys and Ureters: MRI detects tumors, cysts,...
285

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Imaging the hallmarks of cancer.

Nature reviews. Cancer·2026
Same author

NMR-based serum metabolite and lipoprotein profiling for endometriosis across clinically relevant and physiological comparator settings: assessment of diagnostic utility and exploratory biological signals.

BMC medicine·2026
Same author

Impact of DOI Capability on Detector Performance: A Comparative Study of DOI and Non-DOI Detectors for High-Resolution and Sensitivity Organ-Specific PET Inserts.

IEEE transactions on radiation and plasma medical sciences·2026
Same author

Persistent trade-offs balance competition and colonization across centuries.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

The PET tracer [<sup>11</sup>C]MODAG-005 targets alpha-synuclein aggregates in the brain.

Science translational medicine·2026
Same author

Multiomics analysis identifies VPA-induced changes in neural progenitor cells, ventricular-like regions, and cellular microenvironment in dorsal forebrain organoids.

Molecular psychiatry·2026

Related Experiment Video

Updated: Feb 13, 2026

Imaging-Guided Bioreactor for Generating Bioengineered Airway Tissue
11:01

Imaging-Guided Bioreactor for Generating Bioengineered Airway Tissue

Published on: April 6, 2022

3.1K

Linking imaging to omics utilizing image-guided tissue extraction.

Jonathan A Disselhorst1, Marcel A Krueger1, S M Minhaz Ud-Dean1

  • 1Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University Tuebingen, 72076 Tuebingen, Germany.

Proceedings of the National Academy of Sciences of the United States of America
|March 7, 2018
PubMed
Summary
This summary is machine-generated.

This study introduces an image-guided milling machine for precise tissue sampling in small animals. This technology enables accurate in vivo and ex vivo data correlation for better disease characterization.

Keywords:
imagingomicstissue extraction

More Related Videos

A High-Throughput Image-Guided Stereotactic Neuronavigation and Focused Ultrasound System for Blood-Brain Barrier Opening in Rodents
08:02

A High-Throughput Image-Guided Stereotactic Neuronavigation and Focused Ultrasound System for Blood-Brain Barrier Opening in Rodents

Published on: July 16, 2020

5.5K
Cerenkov Luminescence Imaging of Interscapular Brown Adipose Tissue
06:28

Cerenkov Luminescence Imaging of Interscapular Brown Adipose Tissue

Published on: October 7, 2014

13.8K

Related Experiment Videos

Last Updated: Feb 13, 2026

Imaging-Guided Bioreactor for Generating Bioengineered Airway Tissue
11:01

Imaging-Guided Bioreactor for Generating Bioengineered Airway Tissue

Published on: April 6, 2022

3.1K
A High-Throughput Image-Guided Stereotactic Neuronavigation and Focused Ultrasound System for Blood-Brain Barrier Opening in Rodents
08:02

A High-Throughput Image-Guided Stereotactic Neuronavigation and Focused Ultrasound System for Blood-Brain Barrier Opening in Rodents

Published on: July 16, 2020

5.5K
Cerenkov Luminescence Imaging of Interscapular Brown Adipose Tissue
06:28

Cerenkov Luminescence Imaging of Interscapular Brown Adipose Tissue

Published on: October 7, 2014

13.8K

Area of Science:

  • Biomedical Engineering
  • Medical Imaging
  • Pathology

Background:

  • Phenotypic heterogeneity is a hallmark of diseased tissues, particularly tumors.
  • Multimodal imaging offers in vivo macroscopic insights, while in vitro techniques provide cellular-level ex vivo characterization.
  • Integrating in vivo and ex vivo data requires precise spatial coregistration and rapid sample preparation.

Purpose of the Study:

  • To develop and evaluate an image-guided milling system for precise tissue extraction.
  • To enable accurate spatial correlation between in vivo imaging and ex vivo analyses.
  • To facilitate improved disease characterization through integrated multimodal data.

Main Methods:

  • Development of a novel image-guided milling machine for automated tissue sampling.
  • Utilizing tomographic imaging to delineate volumes of interest for extraction.
  • Implementing a cooling system to maintain sample metabolic stability during extraction.

Main Results:

  • Achieved spatial accuracy of tissue extraction better than 0.25 mm.
  • Demonstrated the capability to precisely extract samples from small laboratory animals and excised organs.
  • Ensured sample metabolic stability through continuous cooling during the milling process.

Conclusions:

  • The developed image-guided milling system enables accurate, image-driven tissue sampling.
  • This technology bridges the gap between in vivo imaging and ex vivo multiomics or histology.
  • Facilitates enhanced understanding of tissue heterogeneity and disease mechanisms.