Related Experiment Video
Updated: Feb 13, 2026

Interphase Fluorescence in situ Hybridization of Bone Marrow Smears of Multiple Myeloma
Published on: April 15, 2022
Light Chain Deposition Disease Associated With Multiple Myeloma Developing in Late Pregnancy
Min Jeong Kim, Joo Hui Kim, Il Young Kim
1Department of Internal Medicine, Pusan National University School of Medicine, Yangsan, Busan, Republic of Korea. dongwon@pusan.ac.kr.
Abstract:
Preeclampsia is the most common cause of proteinuria with hypertension during pregnancy. Primary kidney disease and kidney disease secondary to systemic disorders may rarely occur during pregnancy, resulting in proteinuria. A 34-year-old woman was admitted to our hospital with abdominal distention and lower extremity edema. The pregnancy was terminated at the 24th week of gestation due to preterm labor. Even after the delivery, proteinuria and renal deterioration continued to progress. The M-peak was not found on serum and urine protein electrophoresis. The serum free light chains assay showed absolute elevation of lambda chains at 1013.9 mg/L with a decreased kappa to lambda ratio of 0.05. Kidney biopsy revealed light chain deposition disease with lambda light chain deposits on immunofluorescence. Bone marrow examination was compatible with multiple myeloma. To our knowledge, this is the first reported case of light chain deposition disease associated with multiple myeloma during pregnancy.
More Related Videos
09:41An Organotypic High Throughput System for Characterization of Drug Sensitivity of Primary Multiple Myeloma Cells
Published on: July 15, 2015
10:04Establishment of a Human Multiple Myeloma Xenograft Model in the Chicken to Study Tumor Growth, Invasion and Angiogenesis
Published on: May 1, 2015
Related Concept Videos
Electron Transport Chains
The ETC is comprised of...
Phase Transitions: Sublimation and Deposition
Radical Chain-Growth Polymerization: Chain Branching
Multiple Allele Traits
The Chain Rule
Photoreceptors and Plant Responses to Light