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Intravenous and Intra-amniotic In Utero Transplantation in the Murine Model
Published on: October 9, 2018
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Amniotic Membrane Transplantation in Reconstructive and Regenerative Ophthalmology
Tobias Röck1, Karl Ulrich Bartz-Schmidt1, Johanna Landenberger1
1Centre for Ophthalmology, University of Tübingen, Tübingen, Germany.
Annals of Transplantation
|March 7, 2018
Summary
Amniotic membrane transplantation (AMT) numbers significantly increased from 2001-2016, driven by new surgical techniques and a growing understanding of AMT
Area of Science:
- Ophthalmology
- Regenerative Medicine
- Tissue Engineering
Background:
- Amniotic membrane transplantation (AMT) is a recognized treatment for ocular surface disorders.
- The University Eye Hospital Tübingen has a long history of performing AMT.
Purpose of the Study:
- To analyze the trends in amniotic membrane transplantation (AMT) over 16 years.
- To identify indications, surgical techniques, and outcomes of AMT.
Main Methods:
- Retrospective analysis of 771 AMT cases from January 2001 to December 2016.
- Data sourced from electronic databases and Eye Bank annual reports.
Main Results:
- A significant increase in AMT procedures was observed, more than doubling from the first to the second 8-year period.
- Corneal ulcers and persistent epithelial defects were primary indications.
- Inlay, overlay, and sandwich techniques were favored surgical methods.
Conclusions:
- Amniotic membrane transplantation (AMT) use has significantly increased.
- Factors contributing to this rise include advanced surgical techniques, awareness of therapeutic factors in amniotic membrane, and an aging population.
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