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Standardizing biomarker testing for Canadian patients with advanced lung cancer
Current Oncology (Toronto, Ont.)
|March 7, 2018
Summary
Biomarker testing is crucial for advanced non-small cell lung cancer (NSCLC) patients in Canada. This paper defines the minimum standard of care for biomarker testing, including novel targets, to ensure equitable treatment.
Area of Science:
- Oncology
- Molecular Diagnostics
- Genomics
Background:
- Targeted and immune therapies have improved survival for advanced non-small cell lung cancer (NSCLC).
- Biomarker testing is standard for newly diagnosed NSCLC and upon progression after epidermal growth factor receptor (EGFR) inhibitor treatment.
Purpose of the Study:
- To establish evidence-based recommendations for standard-of-care biomarker testing in the Canadian context for advanced NSCLC.
- To define a minimum standard of care for biomarker testing to ensure equitable treatment for all Canadian NSCLC patients.
Main Methods:
- A consensus of Canadian thoracic oncology experts reviewed evidence for biomarker testing.
- Recommendations cover standard targets (EGFR, ALK, ROS1, BRAF V600, PD-L1) at diagnosis and EGFR T790M upon progression.
- Exploratory targets including MET, RET, HER2, NTRK, RAS, and TP53 were considered for future impact.
Main Results:
- The standard of care necessitates the integration of newly available biomarkers.
- National guidelines may struggle to keep pace with rapid technological advancements in biomarker testing.
Conclusions:
- A defined minimum standard of care for biomarker testing in NSCLC is essential for equitable patient treatment in Canada.
- Continuous incorporation of novel biomarkers is critical for optimal patient management.
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