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Recent developments in the asymmetric Reformatsky-type reaction
1Aix-Marseille Univ, CNRS, Centrale Marseille, iSm2, Marseille, France.
Beilstein Journal of Organic Chemistry
|March 7, 2018
Summary
This review covers key advances in asymmetric Reformatsky-type reactions since 2013. It highlights new methods using chiral substrates and catalytic approaches for stereoselective synthesis.
Area of Science:
- Organic Chemistry
- Asymmetric Synthesis
Background:
- Reformatsky-type reactions are crucial for carbon-carbon bond formation.
- Controlling stereochemistry in these reactions is a significant challenge.
Purpose of the Study:
- To review significant developments in asymmetric Reformatsky-type reactions since 2013.
- To cover both diastereoselective and enantioselective methodologies.
Main Methods:
- Literature review of publications from 2013 onwards.
- Categorization of methods based on substrate control (diastereoselective) and catalyst control (enantioselective).
Main Results:
- Compilation of novel diastereoselective methods utilizing chiral substrates.
- Summary of emerging enantioselective catalytic procedures.
- Identification of trends in asymmetric Reformatsky-type reactions.
Conclusions:
- Significant progress has been made in asymmetric Reformatsky-type reactions.
- Chiral substrate and catalytic approaches offer powerful tools for stereoselective synthesis.
- The field continues to evolve with new methodologies.
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