Related Experiment Video

Updated: Feb 13, 2026

Investigating von Willebrand Factor Pathophysiology Using a Flow Chamber Model of von Willebrand Factor-platelet String Formation
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Investigating von Willebrand Factor Pathophysiology Using a Flow Chamber Model of von Willebrand Factor-platelet String Formation

Published on: August 14, 2017

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Autoregulation of von Willebrand factor function by a disulfide bond switch

Diego Butera1, Freda Passam2, Lining Ju3

  • 1The Centenary Institute, Newtown, New South Wales, Australia.

Science Advances
|March 7, 2018
PubMed
Summary

A disulfide bond switch regulates von Willebrand factor (VWF) binding to platelet receptors. This mechanism, controlled by the A2 domain

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