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Ablation Approaches for Ventricular Fibrillation.

Prabhpreet Singh1, Amit Noheria2

  • 1Tulane Heart and Vascular Institute, Tulane University, 1430 Tulane Avenue, #8548, New Orleans, LA, 70112, USA.

Current Treatment Options in Cardiovascular Medicine
|March 7, 2018
PubMed
Summary
This summary is machine-generated.

Recent advances in mapping and ablation offer new hope for treating ventricular fibrillation (VF). Strategies now target triggers and the VF substrate, improving outcomes for patients with sudden cardiac arrest.

Keywords:
AblationPremature ventricular complexesVentricular fibrillation

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Area of Science:

  • Cardiology
  • Electrophysiology
  • Cardiac Arrhythmias

Background:

  • Invasive electrophysiology (EP) mapping and catheter ablation are standard for many arrhythmias.
  • Ventricular fibrillation (VF) presents unique mapping challenges due to disorganized activation and hemodynamic collapse.

Purpose of the Study:

  • To review recent progress in mapping and ablating ventricular fibrillation (VF).
  • To discuss novel strategies targeting VF triggers and arrhythmogenic substrates.

Main Methods:

  • Identifying and ablating trigger arrhythmias (e.g., premature ventricular complexes, ectopy from outflow tracts).
  • Targeting arrhythmogenic substrates in conditions like Brugada syndrome and cardiomyopathies.
  • Investigating rotor mapping and ablation during VF episodes.

Main Results:

  • Trigger ablation has shown success in preventing VF episodes.
  • Substrate modification, including epicardial ablation, offers new therapeutic avenues.
  • Rotor-based ablation is an emerging strategy for VF management.

Conclusions:

  • Advances in mapping and ablation are transforming VF treatment.
  • These life-saving techniques offer improved outcomes for survivors of sudden cardiac death.