Related Experiment Video
Updated: Feb 13, 2026

Author Spotlight: Simulating Pediatric Cardiac Surgery Using a Neonatal Piglet Model
Published on: May 26, 2023
Pediatric appendicitis with appendicolith often presents with prolonged abdominal pain and a high risk of perforation
Hee Mang Yoon1, Jung Heon Kim2, Jong Seung Lee2
1Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, 05505, South Korea.
Insights
Appendicoliths in children significantly increase the risk of severe appendicitis and perforation. Larger appendicoliths (≥5mm) and adjacent collapse are key indicators of perforation risk.
Area of Science:
- Pediatric Surgery
- Gastroenterology
- Radiology
Background:
- Appendicoliths are a common cause of appendiceal obstruction and acute appendicitis.
- Their presence is associated with a higher perforation rate in pediatric appendicitis cases.
Purpose of the Study:
- To characterize appendicoliths in pediatric appendicitis.
- To assess the clinical significance and risk factors associated with appendicoliths in children.
Main Methods:
- Retrospective study of 269 pediatric patients (<17 years) with preoperative appendicitis diagnosis.
- Analysis of clinical features and contrast-enhanced computed tomography (CECT) findings.
Main Results:
- Appendicoliths were present in 54.6% of patients, with a mean diameter of 5.21 mm.
- The appendicolith group showed prolonged pain, severe symptoms, and a significantly higher perforation rate (43.5% vs. 9.8%).
- Maximal appendicolith diameter (≥5mm) and proximal collapse were significant risk factors for perforation.
Conclusions:
- Pediatric appendicitis with appendicolith frequently presents with prolonged pain and severe symptoms.
- Appendicoliths are a significant risk factor for perforation in pediatric appendicitis, with size and adjacent collapse being critical indicators.
Background:
Appendicolith can cause appendiceal obstruction and acute appendicitis. Its high prevalence may be related to the high perforation rate in pediatric appendicitis. This study assessed the characteristics of appendicolith and its clinical significance in pediatric appendicitis.
Methods:
A retrospective study was performed among children and adolescents younger than 17 years who were preoperatively diagnosed with appendicitis in the pediatric emergency department (ED). A total of 269 patients with a mean age of 9.98 ± 3.37 years were enrolled. Clinical features and contrast-enhanced computed tomography findings were analyzed.
Results:
Among the 269 patients, 147 (54.6%) had appendicoliths, with a mean maximal diameter of 5.21 ± 2.34 mm. Compared to the no appendicolith group, the appendicolith group demonstrated more prolonged abdominal pain (≥ 48 hours) before the ED visit (23.1% vs. 11.5%; P = 0.013), clinical features of severe appendicitis (presence of fever, vomiting, positive urine ketone, and increased C-reactive protein), and higher rate of perforation (43.5% vs. 9.8%; P < 0.001). Multivariate risk factor analysis for perforated appendicitis in the appendicolith group revealed that maximal diameter of 5 mm or more in the appendicolith (adjusted odds ratio [aOR] 2.919; 95% CI 1.325-6.428, P = 0.008) and proximal collapse adjacent to the appendicolith (aOR 2.943; 95% CI 1.344-6.443, P = 0.007) were significant.
Conclusions:
Pediatric appendicitis with appendicolith often presents with prolonged abdominal pain and severe clinical conditions with a high risk of perforation.
Related Concept Videos
Appendicitis-I: Introduction
Etiology: Appendicitis can arise from various causes, primarily rooted in the obstruction of the appendix lumen. Factors contributing to this obstruction include fecal accumulation, lymphoid hyperplasia and, in...
Appendicitis-II: Diagnostic Studies and Management
Diagnosing Appendicitis
It requires a multifaceted approach, starting with a detailed physical examination to pinpoint the location and nature of the pain and identify any associated symptoms. Laboratory tests play a crucial role. A complete Blood Count (CBC) typically reveals leukocytosis (an increased number of...
Esophageal Perforation-I: Introduction
The location of esophageal perforation can vary, occurring anywhere along the esophagus....
Abdominal Aorta
The celiac trunk, a singular artery, divides into the left gastric artery, which...
Relative Risk
Pain

