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Fluvastatin for lowering lipids.

Stephen P Adams1, Sarpreet S Sekhon, Michael Tsang

  • 1Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, 2176 Health Sciences Mall, Medical Block C, Vancouver, BC, Canada, V6T 1Z3.

The Cochrane Database of Systematic Reviews
|March 7, 2018
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This summary is machine-generated.

Fluvastatin effectively lowers LDL cholesterol, total cholesterol, and triglycerides in a dose-dependent manner. However, it is significantly less potent than atorvastatin and rosuvastatin for reducing LDL cholesterol.

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Area of Science:

  • Pharmacology
  • Cardiovascular Medicine
  • Clinical Trials

Background:

  • Fluvastatin is considered the least potent statin.
  • The dose-related impact of fluvastatin on blood lipids requires quantification.

Purpose of the Study:

  • To determine the effects of various fluvastatin doses on total cholesterol, LDL cholesterol, HDL cholesterol, and triglycerides.
  • To assess the dose-variability and adverse effects of fluvastatin.

Main Methods:

  • Systematic review and meta-analysis of 145 randomized controlled trials (RCTs) and before-and-after trials.
  • Included 18,846 participants over 3-12 week treatment periods.
  • Data extracted for dose-response, lipid changes, and withdrawals due to adverse effects (WDAEs).

Main Results:

  • Fluvastatin demonstrated linear dose-response effects on total cholesterol, LDL cholesterol, and triglycerides.
  • LDL cholesterol reduction was 6.0% per doubling of fluvastatin dose.
  • Fluvastatin is 12-fold less potent than atorvastatin and 46-fold less potent than rosuvastatin in lowering LDL cholesterol.

Conclusions:

  • Fluvastatin exhibits a dose-dependent linear effect on lowering total cholesterol, LDL cholesterol, and triglycerides.
  • The potency of fluvastatin is considerably lower compared to atorvastatin and rosuvastatin.
  • Short trial durations and incomplete adverse event reporting limited the assessment of fluvastatin's safety profile.