Related Experiment Video
Updated: Feb 13, 2026
Dynamic Contrast Enhanced Magnetic Resonance Imaging of an Orthotopic Pancreatic Cancer Mouse Model
Published on: April 18, 2015
Measurement of blood-brain barrier permeability using dynamic contrast-enhanced magnetic resonance imaging with
Jonghyun Bae1,2,3, Jin Zhang2,3, Youssef Zaim Wadghiri2,3
1Sackler Institute of Graduate Biomedical Science, New York University School of Medicine, New York, New York.
Purpose:
To investigate the feasibility of measuring the subtle disruption of blood-brain barrier (BBB) using DCE-MRI with a scan duration shorter than 10 min.
Methods:
The extended Patlak-model (EPM) was introduced to include the effect of plasma flow (Fp ) in the estimation of vascular permeability-surface area product (PS). Numerical simulation studies were carried out to investigate how the reduction in scan time affects the accuracy in estimating contrast kinetic parameters. DCE-MRI studies of the rat brain were conducted with Fisher rats to confirm the results from the simulation. Intracranial F98 glioblastoma models were used to assess areas with different levels of permeability. In the normal brain tissues, the Patlak model (PM) and EPM were compared, whereas the 2-compartment-exchange-model (TCM) and EPM were assessed in the peri-tumor and the tumor regions.
Results:
The simulation study results demonstrated that scan time reduction could lead to larger bias in PS estimated by PM (>2000%) than by EPM (<47%), especially when Fp is low. When Fp was high as in the gray matter, the bias in PM-PS (>900%) were larger than that in EPM-PS (<42%). The animal study also showed similar results, where the PM parameters were more sensitive to the scan duration than the EPM parameters. It was also demonstrated that, in the peri-tumor region, the EPM parameters showed less change by scan duration than the TCM parameters.
Conclusion:
The results of this study suggest that EPM can be used to measure PS with a scan duration of 10 min or less.
Insights
The extended Patlak-model (EPM) accurately measures blood-brain barrier (BBB) permeability (PS) in under 10 minutes. This dynamic contrast-enhanced MRI (DCE-MRI) method reduces bias compared to the traditional Patlak model, even with reduced scan times.
Area of Science:
- Medical Imaging
- Neuroscience
- Pharmacokinetics
Background:
- The blood-brain barrier (BBB) integrity is crucial for brain health.
- Assessing BBB disruption is vital for diagnosing and monitoring neurological diseases.
- Dynamic Contrast-Enhanced MRI (DCE-MRI) is a key imaging technique for BBB assessment.
Purpose of the Study:
- To evaluate the feasibility of short (under 10 minutes) DCE-MRI scans for measuring BBB permeability.
- To compare the accuracy of the extended Patlak-model (EPM) against traditional models under reduced scan times.
Main Methods:
- Numerical simulations were performed to assess the impact of scan duration on contrast kinetic parameter estimation.
- DCE-MRI studies were conducted on rat brains with F98 glioblastoma models.
- The extended Patlak-model (EPM) was utilized, incorporating plasma flow (Fp) effects.
- Comparisons were made between EPM, Patlak model (PM), and 2-compartment-exchange-model (TCM) in different brain regions.
Main Results:
- Reduced scan times introduced significant bias in PS estimates using the traditional Patlak model (PM), especially at low plasma flow.
- The extended Patlak-model (EPM) demonstrated substantially lower bias (<47%) in PS estimation compared to PM (>2000%) with reduced scan times.
- Animal studies confirmed that EPM parameters were less sensitive to scan duration than PM parameters.
- In peri-tumor regions, EPM parameters showed less variation with scan duration compared to TCM parameters.
Conclusions:
- The extended Patlak-model (EPM) is a feasible method for measuring vascular permeability-surface area product (PS) using DCE-MRI with scan durations of 10 minutes or less.
- EPM offers improved accuracy and robustness in estimating BBB permeability compared to traditional models under accelerated scanning protocols.
More Related Videos
06:29Real-Time Intravital Multiphoton Microscopy to Visualize Focused Ultrasound and Microbubble Treatments to Increase Blood-Brain Barrier Permeability
Published on: February 5, 2022
07:02Phase Contrast Magnetic Resonance Imaging in the Rat Common Carotid Artery
Published on: September 5, 2018
Related Concept Videos
00:49The Blood-brain Barrier
01:24Magnetic Resonance Imaging
01:27Bioavailability Enhancement: Drug Permeability Enhancement
01:27Imaging Studies IV: Magnetic Resonance Imaging
01:31Magnetic Susceptibility and Permeability
When diamagnetic materials are placed under an external magnetic field, the moments opposite to the field are induced. Hence, the susceptibility for diamagnets has a minimal negative value of 10-5–10-6. Since...
01:05Atomic Nuclei: Magnetic Resonance