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Neurological manifestations in hypoparathyroidism.

A S Girija1, T Type1

  • 1Department of Neurology, Medical College, Calicut, Kerala, India.

Neurology India
|March 7, 2018
PubMed
Summary
This summary is machine-generated.

Hypoparathyroidism can cause rare neurological symptoms like choreoathetosis and seizures. Treatment with calcium and vitamin D3 effectively resolved these neurological issues in all reported cases.

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Area of Science:

  • Neurology
  • Endocrinology

Background:

  • Hypoparathyroidism is a rare endocrine disorder characterized by insufficient parathyroid hormone production.
  • Neurological manifestations are uncommon but can be severe and varied.

Purpose of the Study:

  • To report rare neurological presentations of hypoparathyroidism.
  • To highlight diagnostic challenges and treatment outcomes.

Main Methods:

  • Case series reporting three patients with hypoparathyroidism.
  • Clinical presentation, diagnostic workup (blood tests, imaging), and treatment response were documented.

Main Results:

  • Case 1: A 12-year-old boy with idiopathic hypoparathyroidism presented with paroxysmal kinesogenic choreoathetosis, responsive to carbamazepine.
  • Case 2: A patient with idiopathic hypoparathyroidism experienced mental dullness, bone pain, and neuromuscular irritability.
  • Case 3: A patient with post-thyroidectomy hypoparathyroidism presented with raised intracranial tension. Basal ganglia calcification was noted in idiopathic cases. All patients responded to calcium and vitamin D3 therapy.

Conclusions:

  • Hypoparathyroidism can manifest with diverse and severe neurological symptoms.
  • Early diagnosis and appropriate management with calcium and vitamin D3 are crucial for resolving neurological deficits.