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Related Concept Videos

Partial Fractions01:28

Partial Fractions

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A partial fraction is a component of a rational expression represented as the sum of simpler fractions. When a rational function is expressed as a ratio of two polynomials, it can often be decomposed into a sum of fractions whose denominators are simpler polynomials, typically linear or irreducible quadratic factors. This process is called partial fraction decomposition, and it is used to simplify complex expressions for integration, solving equations, or analysis.Partial fraction decomposition...
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Seizures: Classification01:13

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Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
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Epilepsy and Seizures: Overview01:24

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Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
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Mixtures of Gases: Dalton's Law of Partial Pressures and Mole Fractions03:03

Mixtures of Gases: Dalton's Law of Partial Pressures and Mole Fractions

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Unless individual gases chemically react with each other, the individual gases in a mixture of gases do not affect each other’s pressure. Each gas in a mixture exerts the same pressure that it would exert if it were present alone in the container. The pressure exerted by each individual gas in a mixture is called its partial pressure.
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Dalton's Law of Partial Pressure01:11

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The partial pressure of a gas is a measure of the thermodynamic activity of the gas's molecules. The pressure that a gas would create if it occupied the total volume available is called the gas's partial pressure. If two or more gases are mixed together in a container, the molecules move randomly and collide with each other, causing them to reach thermal equilibrium. When the gases have the same temperature, their molecules have the same average kinetic energy. Thus, each gas obeys the...
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Dosage Regimens: Partial Pharmacokinetic Parameters01:01

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It is not uncommon for complete drug pharmacokinetic profiles to remain elusive in pharmacokinetics. This necessitates certain educated assumptions by pharmacokineticists to determine appropriate dosage regimens without comprehensive pharmacokinetic data from animal or human studies. One prevalent assumption is setting the bioavailability factor, denoted as F, to 1 or 100%. This assumption caters to the scenario where a drug doesn't achieve full systemic absorption, resulting in the patient...
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Gabapentin in refractory partial seizures.

M Dhanaraj1, C U Velmurugendran1

  • 1Department of Neurology, Govt. General Hospital, Madras - 600 003, India.

Neurology India
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Summary
This summary is machine-generated.

Gabapentin shows good efficacy as an add-on therapy for drug-resistant epilepsy, reducing seizure frequency in most patients. However, regular blood monitoring is essential due to potential adverse effects like giddiness and reduced hemoglobin.

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Area of Science:

  • Neurology
  • Clinical Pharmacology

Background:

  • Epilepsy is a neurological disorder characterized by recurrent seizures.
  • Conventional antiepileptic drugs (AEDs) are not effective for all patients, necessitating alternative treatment strategies.

Purpose of the Study:

  • To evaluate the preliminary efficacy and safety of Gabapentin as an add-on therapy in patients with partial or secondary generalized seizures resistant to conventional AEDs.

Main Methods:

  • A study was conducted on 16 patients with refractory epilepsy.
  • Gabapentin was administered as an add-on therapy.
  • Seizure frequency and adverse effects were monitored.

Main Results:

  • A significant reduction in seizure frequency (over 50%) was observed in 69% of patients.
  • Adverse effects were reported in 56.25% of patients, including giddiness, sleepiness, and ataxic gait.
  • Hematological changes, such as reduced hemoglobin and eosinophilia, were noted in some patients.

Conclusions:

  • Gabapentin demonstrates good efficacy as an add-on treatment for drug-resistant epilepsy.
  • Regular hematological monitoring is crucial for patients receiving Gabapentin.
  • Further large-scale studies are warranted to confirm these findings in the local population.