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Rhinocerebral zygomycosis : a clinicopathological study
1Department of Pathology, Nizam's Institute of Medical Sciences, Hyderbad - 500 082, India.
Neurology India
|March 7, 2018
Summary
Rhinocerebral zygomycosis, a fungal infection, was diagnosed in six patients by identifying broad, non-septate hyphae in tissue. Key pathological findings included intense inflammation and angioinvasion leading to tissue damage.
Area of Science:
- Mycology
- Pathology
- Infectious Diseases
Background:
- Rhinocerebral zygomycosis is a rare but aggressive fungal infection.
- It primarily affects immunocompromised individuals, but can occur in others.
- Early diagnosis and treatment are crucial for patient outcomes.
Purpose of the Study:
- To describe the clinicopathological features of rhinocerebral zygomycosis.
- To highlight diagnostic criteria and pathological findings.
- To correlate pathological features with clinical presentation and outcomes.
Main Methods:
- Retrospective analysis of six patient cases.
- Histopathological examination of tissue sections.
- Identification of broad, non-septate hyphae as diagnostic markers.
Main Results:
- Six cases of zygomycosis were identified.
- Four cases presented as rhinocerebral/rhinoorbitocerebral zygomycosis; one as isolated cerebral zygomycosis.
- Pathological findings included intense polymorphonuclear response (4 patients) and angioinvasion with hemorrhage, infarction, and necrosis (3 patients).
Conclusions:
- Broad, non-septate hyphae are definitive diagnostic features of zygomycosis.
- Angioinvasion is a significant pathological finding associated with severe tissue damage.
- Clinicopathological correlation is essential for understanding and managing this infection.
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