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zHSF1 modulates zper2 expression in zebrafish embryos.

Lucas Mennetrier1, Tatiana Lopez1,2,3, Benoist Pruvot2

  • 1a UFR SVTE - UFR Sciences de la Vie, de la Terre et de l'Environnement, Université de Bourgogne Franche-Comté , Dijon , France.

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Heat shock protein 1 (HSF1) influences zebrafish per2 (zper2) gene expression. In darkness, HSF1 boosts zper2, but light exposure reduces this effect, suggesting HSF1 acts as a light-dependent repressor.

Keywords:
crispantsmorpholino knockdownzHSF1zebrafishzper2

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Area of Science:

  • Chronobiology
  • Molecular Biology
  • Zebrafish Models

Background:

  • Heat shock factor 1 (HSF1) is crucial for cellular responses to stress and temperature-mediated circadian rhythm regulation.
  • The per2 gene (period 2) is a key component of the circadian clock machinery in vertebrates.

Purpose of the Study:

  • To investigate the in vivo roles of zebrafish HSF1 (zHsf1), heat, and light in regulating zper2 transcription.
  • To elucidate the dual function of zHsf1 in zper2 expression under different environmental conditions.

Main Methods:

  • Utilized zebrafish embryos as a model system.
  • Administered heat shock (HS) and light exposure.
  • Quantified zper2 gene expression in control and hsf1-morphant zebrafish embryos.

Main Results:

  • Heat shock significantly stimulated zper2 expression in zebrafish embryos during dark conditions.
  • Combined heat shock and light exposure did not show a cumulative effect on zper2 expression.
  • zper2 expression was significantly increased (2.7-fold) in hsf1-morphant embryos after light exposure compared to controls.

Conclusions:

  • zHsf1 positively regulates HS-driven zper2 expression in the dark.
  • zHsf1 appears to act as an attenuator of zper2 expression in the presence of light.
  • These findings highlight the complex, context-dependent role of zHsf1 in circadian gene regulation.