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Published on: May 18, 2018
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Plasma Metabolite Profiles in Response to Chronic Exercise.
Andrea M Brennan1, Mark Benson2, Jordan Morningstar3
1School of Kinesiology and Health Studies, Queen's University, Kingston, Ontario, CANADA.
Medicine and Science in Sports and Exercise
|March 7, 2018
Summary
Chronic exercise training did not significantly alter plasma metabolites in obese adults. However, certain metabolites were identified as potential biomarkers reflecting improvements in cardiometabolic health.
Area of Science:
- Exercise physiology
- Metabolomics
- Cardiometabolic health
Background:
- High-throughput metabolomics enables assessment of small molecules in exercise-induced pathways.
- Metabolite profiles can indicate cardiometabolic risk modification.
Purpose of the Study:
- To characterize plasma metabolite profile changes in patients undergoing chronic exercise training.
- To assess the relationship between metabolites and cardiometabolic response to exercise.
Main Methods:
- Secondary analysis of 216 middle-aged, abdominally obese men and women.
- Randomization into 4 groups (exercise amount/intensity variations) or control for 6 months.
- Profiling of 147 metabolites using liquid chromatography-tandem mass spectrometry.
Main Results:
- No significant plasma metabolite changes between exercise and control groups at Bonferroni significance after 24 weeks.
- Seven metabolites showed changes in the exercise group (P < 0.05).
- Several metabolites were associated with changes in cardiometabolic risk traits; three baseline metabolites predicted these changes.
Conclusions:
- Metabolomic profiling showed no significant plasma metabolite alterations with exercise versus control at stringent significance.
- Circulating biomarkers predictive or reflective of cardiometabolic improvements were identified in the exercise group.
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