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Relapse in dermatofibrosarcoma protuberans: A histological and molecular analysis
André S Molina1, João P Duprat Neto1, Eduardo Bertolli1
1Skin Cancer Department, AC Camargo Cancer Hospital, São Paulo, Brazil.
Journal of Surgical Oncology
|March 7, 2018
Summary
Surgical margins less than 2cm are linked to higher dermatofibrosarcoma (DFSP) recurrence. A 2cm margin is acceptable for DFSP treatment, though FasL expression may indicate recurrence risk with smaller margins.
Area of Science:
- Oncology
- Surgical Pathology
- Dermatology
Background:
- Dermatofibrosarcoma protuberans (DFSP) is a rare, low-grade tumor.
- DFSP exhibits locally aggressive behavior with low metastatic potential.
Purpose of the Study:
- To identify factors associated with tumor relapse in DFSP patients.
- To evaluate the impact of surgical margins and molecular markers on DFSP recurrence.
Main Methods:
- Retrospective analysis of 61 DFSP patient medical records.
- Fluorescence in situ hybridization (FISH) used to detect chromosomal translocations.
- Immunohistochemical analysis of markers, including FasL.
Main Results:
- Six out of 61 patients experienced recurrence.
- No recurrence observed with resection margins >3cm.
- Recurrence rates were significantly higher for margins <2cm (P=0.018).
- FasL expression correlated with recurrence in patients with margins <3cm.
Conclusions:
- Surgical margins <2cm are associated with increased DFSP recurrence.
- A 2cm surgical margin appears acceptable for DFSP treatment.
- FasL expression is a potential indicator of recurrence risk, particularly with margins <3cm.
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