Could antiretrovirals be treating EBV in MS? A case report
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Updated: Feb 13, 2026

Methods Development for Blood Borne Macrophage Carriage of Nanoformulated Antiretroviral Drugs
Published on: December 9, 2010
Natalia C Drosu1, Elazer R Edelman2, David E Housman3
1Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, United States; Health Sciences & Technology, Harvard Medical School, Boston, MA, United States.
Abstract:
We present the case of an HIV-negative patient clinically diagnosed with relapsing-remitting MS who achieved significant disease improvement on Combivir (zidovudine/lamivudine). Within months of treatment, the patient reported complete resolution of previously unremitting fatigue and paresthesiae, with simultaneous improvements in lesion burden detected by MRI. All improvements have been sustained for more than three years. This response may be related to the action of zidovudine as a known inhibitor of EBV lytic DNA replication, suggesting future directions for clinical investigation.
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