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Updated: Feb 13, 2026

Smartphone Fundus Photography
Published on: July 6, 2017
Fundus changes in type III membranoproliferative glomerulonephritis: a case report
Masato Takei1,2, Akira Obana3, Takenori Inomata4,5
1Department of Ophthalmology, Japan Red Cross Medical Center, 4-1-22, Hiroo, Shibuya-ku, Tokyo, Japan.
Background:
Membranoproliferative glomerulonephritis (MPGN) is characterized by mesangial cell proliferation and is classified into types I, II and III based on structural changes in the glomerular capillary walls. The drusen-like deposits of MPGN type II have been studied, but the fundus changes in MPGN type III have yet to be clarified. We report a case of MPGN type III with multiple deposits in the retinal pigment epithelium (RPE).
Case Presentation:
A 40-year-old Japanese woman with MPGN type III developed numerous yellow-white patches in the central macula of both eyes. Optical coherence tomography (OCT) showed deposits between the RPE and Bruch's membrane. Fluorescein angiography showed choroidal neovascularization (CNV) and OCT confirmed it as type 1 (sub RPE) CNV with fibrin tissue and subretinal fluid in the right eye. After 12 months, the CNV and subretinal fluid resolved spontaneously but the RPE deposits remained in both eyes. Her final visual acuity was 20/20 in the right eye and 20/16 in the left eye.
Conclusion:
We report a case of MPGN type III with multiple deposits in the RPE and CNV, suggesting that various fundus changes occur in MPGN type III and careful fundus follow-up is necessary to prevent vision loss.
Insights
Membranoproliferative glomerulonephritis (MPGN) type III can cause retinal pigment epithelium (RPE) deposits and choroidal neovascularization (CNV). Careful fundus monitoring is crucial for patients with MPGN type III to prevent vision loss.
Area of Science:
- Ophthalmology
- Nephrology
- Pathology
Background:
- Membranoproliferative glomerulonephritis (MPGN) is classified into three types based on glomerular capillary wall structural changes.
- While MPGN type II deposits are studied, fundus changes in MPGN type III remain unclear.
- This study reports a case of MPGN type III with retinal pigment epithelium (RPE) deposits.
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