Treatment of diabetic gastroparesis with oral domperidone

Three patients with severe diabetic gastroparesis unresponsive to metoclopramide were found to have markedly prolonged gastric half-emptying times (t1/2) using a radionuclide-labelled test meal. They all showed symptomatic improvement and normal t1/2 within one week of taking oral domperidone 10 mg q.d.s. Oral domperidone may have a role in the treatment of severe diabetic gastroparesis particularly in metoclopramide-resistant cases.