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Glycosylated haemoglobin levels in patients referred for oral glucose tolerance tests

W G John, R W Richardson

    Diabetic Medicine : a Journal of the British Diabetic Association
    |January 1, 1986
    PubMed

    Insights

    Glycosylated haemoglobin (GHb) effectively distinguishes diabetes, showing no overlap between diabetic and normal patients. GHb also strongly correlates with blood glucose levels measured during oral glucose tolerance tests (OGTTs).

    Area of Science:

    • Endocrinology
    • Clinical Chemistry
    • Diabetes Mellitus Research

    Background:

    • Oral glucose tolerance tests (OGTTs) are standard for diagnosing diabetes, but Glycosylated haemoglobin (GHb) offers a complementary measure.
    • Assessing GHb alongside OGTTs can improve diagnostic accuracy and understanding of glucose metabolism.

    Purpose of the Study:

    • To evaluate the diagnostic utility of GHb in relation to WHO criteria for OGTTs.
    • To investigate the correlation between GHb levels and blood glucose concentrations during OGTTs in a patient cohort.

    Main Methods:

    • Performed OGTTs on 127 patients, interpreting results using WHO criteria.
    • Measured GHb using affinity chromatography on fasting blood samples.
    • Analyzed correlations between GHb and various blood glucose measurements (fasting, 2-hour, and mean OGTT values).

    Main Results:

    • All diabetic patients had GHb >9.9%, with no overlap with the normal group (GHb <8.8%).
    • GHb showed strong correlations with fasting and 2-hour blood glucose in diabetic patients.
    • The strongest correlation overall was between GHb and the mean blood glucose from the OGTT.

    Conclusions:

    • GHb is a reliable indicator for diagnosing diabetes, with distinct ranges for diabetic and normal individuals.
    • GHb measurements correlate well with glucose tolerance, particularly with the mean glucose level during an OGTT.
    • This study supports GHb as a valuable tool in diabetes assessment, complementing OGTT results.

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