Related Experiment Video
Updated: Feb 13, 2026

Mechanism of Kemeng Fang's Inhibition of Podocyte Apoptosis in Rats with Membranous Nephropathy through the PI3K/AKT Signaling Pathway
Published on: August 23, 2024
SRPX2 regulates colon cancer cell metabolism by miR-192/215 via PI3K-Akt
Jian Zhao1, Jian Xu1, Rui Zhang1
1Department of Colorectal Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & InstituteShenyang, China.
Abstract:
Colon cancer is one of common cancer in the world and glycolysis is one of the major problems in colon cancer therapy. MicroRNAs (miRNAs) involve in colon cancer progression. Sushi repeat-containing protein X-linked 2 (SRPX2) is associated with poor prognosis in some cancer patients, however, the role of SRPX2 including glycolytic metabolism regulated by miRNAs is unclear in colon cancer. So, the purpose of the present study is to elucidate the underlying mechanism in colon cancer metabolism mediated by SRPX2. Our results revealed that miR-192-5p (miR-192) and miR-215-5p (miR-215) inhibited glycolysis by regulating SRPX2 expression in colon cancer cells. We also found that miR-192 and miR-215 were both regulated by PI3K-Akt. Our results indicate that SRPX2 facilitates colon cancer cell glycolysis by miR-192 and miR-215, which are down-regulated by PI3K-Akt.
Related Concept Videos
PI3K/mTOR/AKT Signaling Pathway
Regulation of Metabolism
The Colonization of Land
What is Metabolism?
pH Regulation in Cells
Cytosolic pH
Under physiological conditions, the cytosolic pH is slightly more acidic than the extracellular pH. However, cells must prevent further acidification of their cytosol to...
Regulated Protein Degradation
Protein degradation plays two important roles in the cells. It helps to protect cells from misfolded or damaged proteins before they lead to a...

