Chlorpropamide lowers serum and lipoprotein cholesterol in insulin-dependent diabetes

Changes in serum lipids and lipoproteins were examined during eight weeks chlorpropamide therapy in eight C-peptide negative, insulin-dependent diabetic patients (mean age 40 years, mean onset of diabetes 20 years). Chlorpropamide was found to have a generalized cholesterol lowering effect (progressive significant fall in mean total cholesterol, LDL-C, HDL-C, and HDL3-C) with no significant change in the ratio of high-density lipoprotein to low-density lipoprotein cholesterol which was independent of insulin secretion.