Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cis-regulatory Sequences02:02

Cis-regulatory Sequences

11.9K
Cis-regulatory sequences are short fragments of non-coding DNA that are present on the same chromosomes as the genes that they regulate. These fragments serve as binding sites for transcriptional regulators, proteins that are responsible for controlling gene transcription and differential gene expression across cell types in eukaryotes. Cis-regulatory sequences can be close to the gene of interest or thousands of bases away in the DNA sequence; however, those sequences that are further away are...
11.9K
Cis-regulatory Sequences02:02

Cis-regulatory Sequences

4.2K
4.2K
Nose and Nasal Cavity01:24

Nose and Nasal Cavity

12.4K
The nose is composed of an observable exterior segment (external nose) and an internal segment within the skull known as the nasal cavity (internal nose). The external nose, visible on the face, consists of a framework of bone and hyaline cartilage enveloped in skin and muscle and lined with a mucous membrane. This structure is supported by the frontal bone, nasal bones, and maxillary bone and is supplemented by a cartilaginous framework comprising the septal nasal cartilage, lateral nasal...
12.4K
Global Regulatory Systems01:28

Global Regulatory Systems

732
Global regulatory systems in bacteria enable rapid and coordinated responses to environmental changes by integrating sensory inputs with gene expression, ensuring efficient adaptation to fluctuating conditions. Key global regulatory mechanisms include regulons, two-component systems, sigma factors, and secondary messengers.Regulons and Global RegulatorsA regulon is a collection of genes and operons controlled by a common global regulator. These regulators enable bacteria to prioritize resource...
732
Administering Oxygen by Nasal Cannula01:29

Administering Oxygen by Nasal Cannula

3.4K
Oxygen therapy is critical to patient care, especially for those struggling with respiratory issues. This intervention increases the oxygen concentration in the lungs, enhancing the amount of oxygen transported to the body's tissues. One standard method of delivering supplemental oxygen is through a nasal cannula, a non-invasive device that provides low to medium oxygen concentrations.
Nasal Cannulas
A nasal cannula is a lightweight tube split into two prongs placed in the nostrils,...
3.4K
Oxygen Delivering System I: Nasal Cannula and Face Mask01:26

Oxygen Delivering System I: Nasal Cannula and Face Mask

1.8K
The human body requires oxygen to function, and when the natural process of respiration is hindered, external devices, including the following, are needed to help deliver this vital gas.
Nasal Cannula
A nasal cannula is a lightweight tube split at one end into two prongs and placed in the nostrils. It is typically used to deliver low to medium levels of oxygen.
Suggested flow rate: The suggested flow rate for a nasal cannula typically ranges between 1 and 6 L/min.
Oxygen percentage setting:...
1.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evaluating the interpretation of neck CT/MRI scans by ChatGPT-4V for detecting primary oropharyngeal squamous cell carcinoma: An exploratory study.

European annals of otorhinolaryngology, head and neck diseases·2026
Same author

[Use of Omalizumab-biosimilars for CRSwNP in the German Health Care System - a Position Paper of the German Societies for Allergy AeDA and ORL DGHNO-KHC].

Laryngo- rhino- otologie·2026
Same author

Lack of De-Intensification Models for Female Head and Neck Cancer Patients With Favorable Prognosis.

Cancer medicine·2026
Same author

Otitis Media With Effusion (OME) and Eustachian Tube Dysfunction: The Role of Allergy and Immunity-An EAACI Position Paper.

Allergy·2025
Same author

Laryngo- rhino- otologie·2023
Same author

Laryngo- rhino- otologie·2023

Related Experiment Video

Updated: Feb 13, 2026

Saline Lavage for Sampling of the Canine Nasal Immune Microenvironment
04:35

Saline Lavage for Sampling of the Canine Nasal Immune Microenvironment

Published on: December 27, 2024

1.0K

[Regulatory dysfunctions in nasal polyposis].

M Koennecke1, R Pries2, B Wollenberg2

  • 1Klinik für Hals‑, Nasen- und Ohrenheilkunde, Universitätsklinikum Schleswig-Holstein, Campus Lübeck, Ratzeburger Allee 160, 23538, Lübeck, Deutschland. Michael.Koennecke@uksh.de.

HNO
|March 8, 2018
PubMed
Summary
This summary is machine-generated.

Chronic rhinosinusitis with nasal polyps (CRSwNP) is complex. Gene expression studies reveal altered cell adhesion and blood vessels, offering insights into pathogenesis and new therapeutic strategies for this inflammatory condition.

Keywords:
Nasal mucosaNasal polypsParanasal sinus diseasesRhinitisSinusitis

More Related Videos

Culture and Imaging of Human Nasal Epithelial Organoids
13:20

Culture and Imaging of Human Nasal Epithelial Organoids

Published on: December 17, 2021

4.5K
Culturing of Human Nasal Epithelial Cells at the Air Liquid Interface
10:38

Culturing of Human Nasal Epithelial Cells at the Air Liquid Interface

Published on: October 8, 2013

38.3K

Related Experiment Videos

Last Updated: Feb 13, 2026

Saline Lavage for Sampling of the Canine Nasal Immune Microenvironment
04:35

Saline Lavage for Sampling of the Canine Nasal Immune Microenvironment

Published on: December 27, 2024

1.0K
Culture and Imaging of Human Nasal Epithelial Organoids
13:20

Culture and Imaging of Human Nasal Epithelial Organoids

Published on: December 17, 2021

4.5K
Culturing of Human Nasal Epithelial Cells at the Air Liquid Interface
10:38

Culturing of Human Nasal Epithelial Cells at the Air Liquid Interface

Published on: October 8, 2013

38.3K

Area of Science:

  • Immunology
  • Molecular Biology
  • Otorhinolaryngology

Background:

  • Chronic rhinosinusitis (CRS) is a diverse inflammatory condition with substantial healthcare costs.
  • Current understanding lacks a unified signaling pathway explaining CRS pathogenesis and tissue changes.
  • No single treatment effectively addresses the heterogeneity of CRS.

Purpose of the Study:

  • To investigate molecular and genetic characteristics of chronic rhinosinusitis with nasal polyps (CRSwNP).
  • To identify specific molecular pathways and mechanisms involved in CRSwNP pathogenesis.
  • To explore potential targets for novel therapeutic interventions in CRSwNP.

Main Methods:

  • Gene expression profiling using microarray analysis in CRSwNP tissues.
  • Molecular biologic investigations to identify key pathogenetic mechanisms.
  • Analysis of cellular infiltration patterns, specifically eosinophils and Th2 inflammation.

Main Results:

  • Microarray analysis identified significant alterations in cell adhesion and differentiation pathways.
  • Changes in blood vessel characteristics were observed in CRSwNP tissues.
  • Two key mechanisms potentially driving nasal polyp pathogenesis were identified.

Conclusions:

  • Findings suggest that altered cell adhesion, differentiation, and vascularization contribute to CRSwNP.
  • These molecular insights may elucidate the pathogenesis of nasal polyps within a Th2-mediated inflammatory context.
  • The study provides a basis for developing targeted, novel therapeutic strategies for CRSwNP.