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Oral dosing of rodents using a palatable tablet.
Sandeep S Dhawan1, Shuang Xia1, David S Tait2
1School of Psychology and Neuroscience, University of St Andrews, St Mary's Quad, South Street, St Andrews, Fife, KY16 9JP, UK.
Psychopharmacology
|March 8, 2018
Summary
Palatable jelly tablets offer a stress-free method for delivering orally bioavailable drugs like modafinil to rodents. This novel approach provides an effective alternative to oral gavage, ensuring consistent drug delivery and behavioral effects.
Area of Science:
- Pharmacology
- Drug Delivery Systems
- Rodent Models
Background:
- Oral drug administration in rodents is crucial for human treatment development.
- Traditional oral gavage is stressful, requires training, and risks esophageal damage.
Purpose of the Study:
- To evaluate palatable gelatin tablets as a novel, stress-free oral drug delivery method.
- To assess the efficacy of this method for delivering the wake-promoting drug modafinil.
Main Methods:
- Modafinil (30 mg/kg) was administered to rats via palatable jelly tablets.
- Brain tissue concentrations and locomotor activity were measured at various time points.
- Data was compared to previous oral gavage and intraperitoneal injection studies.
Main Results:
- Modafinil was detected in brain tissue throughout the study, with concentrations decreasing over time.
- The brain concentration pattern mirrored previous oral gavage results.
- Modafinil-treated rats exhibited increased locomotor activity, particularly in later time periods.
Conclusions:
- Palatable jelly tablets are an effective delivery method for thermally stable, orally bioavailable compounds.
- This method avoids the stress and risks associated with oral gavage.
- It presents a viable alternative to other palatable routes, avoiding potential gastrointestinal absorption issues.
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