Related Experiment Video
Updated: Feb 13, 2026
07:14
Synthesis of Bimetallic Pt/Sn-based Nanoparticles in Ionic Liquids
Published on: August 23, 2018
9.5K
Ionic liquids as biocompatible stabilizers of proteins
Mouhamad Reslan1, Veysel Kayser2
1Faculty of Pharmacy, The University of Sydney, Sydney, NSW, 2006, Australia.
Biophysical Reviews
|March 8, 2018
Summary
Ionic liquids (ILs) show promise for stabilizing proteins and enzymes. This review explores their potential in biopharmaceutical formulation, focusing on biocompatibility and stability for therapeutic proteins.
Area of Science:
- Biotechnology and biopharmaceutical development
- Protein stabilization and formulation science
- Green chemistry and novel solvent applications
Background:
- Biopharmaceuticals, including therapeutic proteins and vaccines, are crucial for treating diseases like cancer and autoimmune disorders.
- Protein stability is critical for the efficacy and shelf-life of biopharmaceuticals, requiring effective stabilization strategies.
- Current stabilization methods face challenges in manufacturing, transport, and long-term storage, necessitating novel approaches.
Purpose of the Study:
- To review the recent advancements in using ionic liquids (ILs) for stabilizing proteins and enzymes.
- To assess the potential of ILs as excipients in biopharmaceutical formulations.
- To identify biocompatible ILs suitable for developing stable therapeutic proteins.
Main Methods:
- Literature review of studies on ionic liquids and protein/enzyme stabilization.
- Analysis of IL properties relevant to biopharmaceutical formulation (e.g., viscosity, osmolality).
- Evaluation of IL toxicity and biocompatibility data for human applications.
Main Results:
- Ionic liquids demonstrate significant potential as stabilizers for proteins and enzymes.
- Certain ionic liquids exhibit favorable properties for biopharmaceutical formulation.
- Understanding IL-protein interactions and toxicity is key to their successful application.
Conclusions:
- Ionic liquids offer a promising avenue for enhancing the stability of therapeutic proteins.
- Further research into biocompatible ionic liquids is essential for their integration into biopharmaceutical formulations.
- Ionic liquids could revolutionize the development of stable and effective biopharmaceuticals.
Related Concept Videos
03:10Ionic Radii
33.9K
Ionic radius is the measure used to describe the size of an ion. A cation always has fewer electrons and the same number of protons as the parent atom; it is smaller than the atom from which it is derived. For example, the covalent radius of an aluminum atom (1s22s22p63s23p1) is 118 pm, whereas the ionic radius of an Al3+ (1s22s22p6) is 68 pm. As electrons are removed from the outer valence shell, the remaining core electrons occupying smaller shells experience a greater effective nuclear...
33.9K
00:42Ionic Bonds
132.2K
Overview
When atoms gain or lose electrons to achieve a more stable electron configuration they form ions. Ionic bonds are electrostatic attractions between ions with opposite charges. Ionic compounds are rigid and brittle when solid and may dissociate into their constituent ions in water. Covalent compounds, by contrast, remain intact unless a chemical reaction breaks them.
Opposing Charges Hold Ions Together in Ionic Compounds
Ionic bonds are reversible electrostatic interactions between ions...
When atoms gain or lose electrons to achieve a more stable electron configuration they form ions. Ionic bonds are electrostatic attractions between ions with opposite charges. Ionic compounds are rigid and brittle when solid and may dissociate into their constituent ions in water. Covalent compounds, by contrast, remain intact unless a chemical reaction breaks them.
Opposing Charges Hold Ions Together in Ionic Compounds
Ionic bonds are reversible electrostatic interactions between ions...
132.2K
02:54Molecular and Ionic Solids
20.3K
Crystalline solids are divided into four types: molecular, ionic, metallic, and covalent network based on the type of constituent units and their interparticle interactions.
Molecular Solids
Molecular crystalline solids, such as ice, sucrose (table sugar), and iodine, are solids that are composed of neutral molecules as their constituent units. These molecules are held together by weak intermolecular forces such as London dispersion forces, dipole-dipole interactions, or hydrogen bonds, which...
Molecular Solids
Molecular crystalline solids, such as ice, sucrose (table sugar), and iodine, are solids that are composed of neutral molecules as their constituent units. These molecules are held together by weak intermolecular forces such as London dispersion forces, dipole-dipole interactions, or hydrogen bonds, which...
20.3K
02:55Solubility of Ionic Compounds
68.3K
Solubility is the measure of the maximum amount of solute that can be dissolved in a given quantity of solvent at a given temperature and pressure. Solubility is usually measured in molarity (M) or moles per liter (mol/L). A compound is termed soluble if it dissolves in water.
68.3K
02:42Ionic Crystal Structures
17.9K
Ionic crystals consist of two or more different kinds of ions that usually have different sizes. The packing of these ions into a crystal structure is more complex than the packing of metal atoms that are the same size.
Most monatomic ions behave as charged spheres, and their attraction for ions of opposite charge is the same in every direction. Consequently, stable structures for ionic compounds result (1) when ions of one charge are surrounded by as many ions as possible of the opposite...
Most monatomic ions behave as charged spheres, and their attraction for ions of opposite charge is the same in every direction. Consequently, stable structures for ionic compounds result (1) when ions of one charge are surrounded by as many ions as possible of the opposite...
17.9K
03:34Ionic Compounds: Formulas and Nomenclature
88.1K
An element composed of atoms that readily lose electrons (a metal) can react with an element composed of atoms that readily gain electrons (a nonmetal) to produce ions through complete electron transfer. The compound formed by this transfer is stabilized by the electrostatic attractions (ionic bonds) between the oppositely charged ions.
88.1K