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Autoimmune Disorders01:29

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Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
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Pancreatic Juice and Secretion01:26

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Autoimmune Pancreatitis Mouse Model.

Ken Kamata1, Tomohiro Watanabe1,2, Kosuke Minaga1

  • 1Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Osaka-Sayama, Osaka, Japan.

Current Protocols in Immunology
|March 8, 2018
PubMed
Summary
This summary is machine-generated.

Autoimmune pancreatitis (AIP) is a pancreatic manifestation of IgG4-related disease (IgG4-RD). An experimental model in mice reveals insights into the immuno-pathogenesis of this IgG4-related AIP.

Keywords:
IgG4-related diseaseautoimmune pancreatitisplasmacytoid dendritic cells

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Area of Science:

  • Immunology
  • Gastroenterology
  • Pathology

Background:

  • Autoimmune pancreatitis (AIP) is a chronic fibro-inflammatory pancreatic disorder.
  • AIP is now recognized as a pancreatic manifestation of IgG4-related disease (IgG4-RD), a systemic condition.
  • IgG4-RD involves IgG4 antibody responses and inflammation in multiple organs.

Purpose of the Study:

  • To investigate the molecular mechanisms underlying experimental autoimmune pancreatitis (AIP).
  • To provide insights into the immuno-pathogenesis of human IgG4-related AIP using a mouse model.

Main Methods:

  • Utilized autoimmune-prone MRL/Mp mice.
  • Administered repeated injections of polyinosinic-polycytidylic acid (poly(I:C)) to induce experimental AIP.
  • Observed pancreatic architecture, immune cell infiltration, and fibrosis.

Main Results:

  • Experimental AIP in mice showed massive pancreatic destruction, immune cell infiltration, and fibrosis.
  • The experimental model exhibited multi-organ involvement and elevated autoantibodies, mimicking human IgG4-RD.
  • Mice lacking the IgG4 antibody subtype were used to model AIP.

Conclusions:

  • The experimental AIP model in mice offers valuable insights into human IgG4-related AIP.
  • Understanding the molecular mechanisms of experimental AIP can elucidate the immuno-pathogenesis of IgG4-RD.