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Design and Development of Biomimetic Nanovesicles Using a Microfluidic Approach
Roberto Molinaro1,2, Michael Evangelopoulos1, Jessica R Hoffman1
1Center of Biomimetic Medicine, Houston Methodist Research Institute, 6670 Bertner Avenue, Houston, TX, 77030, USA.
Advanced Materials (Deerfield Beach, Fla.)
|March 8, 2018
Summary
Microfluidics enables scalable production of biomimetic nanovesicles (NA-Leuko) with preserved cell functions for drug delivery. This manufacturing method ensures consistency and high throughput for advanced nanomedicine platforms.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Materials Science
Background:
- Biomimetic and biohybrid platforms offer advantages for drug delivery but lack scalable manufacturing.
- Current methods struggle with standardization, consistency, and high-throughput production of these advanced nanocarriers.
Purpose of the Study:
- To demonstrate a microfluidic-based platform for manufacturing biomimetic nanovesicles (leukosomes) with incorporated membrane proteins.
- To characterize the physical, pharmaceutical, and biological properties of these microfluidic-formulated nanovesicles (NA-Leuko).
Main Methods:
- Utilized a microfluidic platform for controlled synthesis of biomimetic nanovesicles.
- Incorporated membrane proteins into the lipid bilayer of leukosomes.
- Characterized NA-Leuko for shelf life, physical properties, and biological function retention.
Main Results:
- Microfluidic formulation resulted in NA-Leuko with extended shelf life.
- NA-Leuko retained the biological functions of donor cells, including macrophage avoidance.
- Demonstrated targeting of inflamed vasculature by NA-Leuko.
Conclusions:
- The microfluidic approach provides a versatile, robust, and scalable method for manufacturing biomimetic nanovesicles.
- NA-Leuko represent a promising platform for drug delivery, maintaining biological relevance and stability.
- This adaptable nanotechnology manufacturing tool facilitates the development of advanced nanomedicine.
Keywords:
bioinspired approachinflammationmembrane protein incorporationmicrofluidicsmolecular dynamicsMore Related Videos
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