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Related Concept Videos

Arteries of the Head and Neck01:26

Arteries of the Head and Neck

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The human body's intricate network of arteries ensures that every organ system receives the necessary oxygen and nutrients for optimal function. The arterial network in the head and neck region is particularly complex, providing vital blood flow to the brain, eyes, and other critical structures. Prominent arteries in this region include the internal carotid arteries and the vertebral arteries.
The internal carotid arteries supply blood to the anterior portion of the cerebrum. They enter the...
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Veins of Head and Neck01:19

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The blood drainage from the head and neck is primarily managed by three pairs of veins: the external jugular, internal jugular, and vertebral veins. The external jugular veins drain superficial scalp and face structures, passing over the sternocleidomastoid muscles to empty into the subclavian veins.
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Genomics02:02

Genomics

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Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
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Hepatic Portal System01:21

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The hepatic portal system, a critical part of our circulatory framework, transports nutrient-laden, deoxygenated blood from the gastrointestinal tract and spleen to the liver. This ingenious system plays an indispensable role in maintaining our body's metabolic equilibrium.
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Muscles of the Anterior Neck01:26

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The anterior neck muscles are the group of muscles covering the front part of the neck. These muscles are classified into three subgroups. The first one is the superficial muscles, the most visible muscles in the front of the neck. It includes the platysma and sternocleidomastoid. The second group is the suprahyoid muscles, located above the hyoid bone. This group comprises the digastric, mylohyoid, geniohyoid, and stylohyoid. Lastly, the infrahyoid muscles are found below the hyoid bone and...
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Genomic Imprinting and Inheritance

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Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
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Related Experiment Video

Updated: Feb 13, 2026

In Vitro Establishment of a Genetically Engineered Murine Head and Neck Cancer Cell Line using an Adeno-Associated Virus-Cas9 System
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In Vitro Establishment of a Genetically Engineered Murine Head and Neck Cancer Cell Line using an Adeno-Associated Virus-Cas9 System

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GENIPAC: A Genomic Information Portal for Head and Neck Cancer Cell Systems.

B K B Lee1,2, C P Gan1, J K Chang3,4

  • 11 Head and Neck Cancer Research Team, Cancer Research Malaysia, Subang Jaya, Malaysia.

Journal of Dental Research
|March 8, 2018
PubMed
Summary

GENIPAC is a new web resource providing accessible genomics data for 44 head and neck cancer (HNC) cell lines. This tool aids researchers in understanding HNC development and advancing precision therapies.

Keywords:
bioinformaticsbiomarkerscancer biologygene expressiongenomicsoral carcinogenesis

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Area of Science:

  • Genomics
  • Bioinformatics
  • Cancer Research

Background:

  • Head and neck cancer (HNC) cell lines are crucial for studying cancer biology and developing precision therapies.
  • Accessing and analyzing genomic data from HNC cell lines often requires specialized bioinformatics and computational skills.
  • Existing databases may present challenges in data mining and interpretation for researchers without extensive expertise.

Purpose of the Study:

  • To develop a user-friendly web resource, GENIPAC, for exploring, visualizing, and analyzing genomics information of commonly used HNC cell lines.
  • To consolidate and present genomic data from multiple studies in an easily accessible format.
  • To facilitate a better understanding of HNC and accelerate the development of targeted therapeutic strategies.

Main Methods:

  • Compiled genomics data from 44 HNC cell lines across three studies (ORL Series, OPC-22, H Series).
  • Utilized RNA-sequencing for mRNA expression and mutation analysis, and array/whole exome sequencing for copy number alterations.
  • Preprocessed data using customized scripts and validated using cBioPortal tools.

Main Results:

  • GENIPAC provides integrated access to clinical and genomic information for 44 HNC cell lines.
  • Demonstrated the utility of GENIPAC by analyzing common HNC genomic alterations (e.g., TP53, EGFR, CCND1, PIK3CA) and pathways.
  • Confirmed that genomic alterations in GENIPAC recapitulate findings from The Cancer Genome Atlas (TCGA).

Conclusions:

  • GENIPAC enhances accessibility to crucial genomic information for HNC cell lines.
  • This resource supports the research community in advancing HNC understanding and precision medicine.
  • GENIPAC aims to accelerate the discovery of novel therapeutic targets and treatment options for head and neck cancer.