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Multicomponent Pharmaceutical Cocrystals: A Novel Approach for Combination Therapy.

Dipti Srivastava1, Zeeshan Fatima2, Chanchal Deep Kaur3

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Cocrystallization enables multi-API drug formulations, overcoming challenges in combination therapy. These drug-drug cocrystals improve physicochemical properties for complex disorders.

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Area of Science:

  • Pharmaceutical Science
  • Materials Science
  • Drug Delivery

Background:

  • Cocrystallization modifies active pharmaceutical ingredient (API) properties using supramolecular synthons.
  • Most cocrystals involve an API and a Generally Recognized As Safe (GRAS) coformer.
  • Few studies explore cocrystals composed of two or more APIs (multi-API cocrystals).

Purpose of the Study:

  • To review existing drug-drug cocrystals.
  • To provide insights for designing improved multi-API cocrystals.
  • To explore applications in multiple target therapy.

Main Methods:

  • Literature review of drug-drug cocrystal studies.
  • Analysis of non-covalent interactions in multi-API cocrystal formation.
  • Evaluation of physicochemical and pharmacokinetic property modifications.

Main Results:

  • Multi-API cocrystals are formed via non-covalent interactions between APIs, retaining activity.
  • Drug-drug cocrystals address solubility and stability issues in traditional combination therapy.
  • Cocrystallization offers a strategy for delivering combination drugs for complex diseases.

Conclusions:

  • Multi-API cocrystals present a promising approach for combination drug delivery.
  • Designing drug-drug cocrystals can enhance therapeutic efficacy for complex disorders.
  • Further research into multi-API cocrystals can optimize treatment strategies.