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The Delicate Equilibrium between Oxidants and Antioxidants in Brain Glioma

María Jesús Ramírez-Expósito1, José Manuel Martínez-Martos1

  • 1Experimental and Clinical Physiopathology Research Group CTS-1039; Department of Health Sciences, Faculty of Health Sciences; University of Jaen, Campus Universitario Las Lagunillas, Jaen, Spain.

Current Neuropharmacology
|March 8, 2018
PubMed

Insights

This review explores how oxidative stress and antioxidant imbalance drive glioma development. Understanding these redox mechanisms could lead to novel treatments for brain tumors.

Area of Science:

  • Neuro-oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Gliomas are common adult brain tumors with limited effective adjuvant therapies.
  • Brain tumor development is linked to increased free radicals and weakened antioxidant defenses.
  • This imbalance contributes to cellular damage and malignant transformation.

Purpose of the Study:

  • To review the role of redox imbalance in glioma development and progression.
  • To analyze the influence of redox status on apoptosis and autophagy in cancer.
  • To provide a basis for new redox-targeted glioma therapies.

Main Methods:

  • Literature review focusing on the role of free radicals and antioxidants in gliomas.
  • Analysis of the impact of redox status on programmed cell death pathways (apoptosis and autophagy).
  • Synthesis of current knowledge on redox mechanisms in brain tumorigenesis.

Main Results:

  • Oxidative stress and impaired antioxidant defenses are key factors in glioma initiation and progression.
  • Redox status significantly influences apoptosis and autophagy, critical processes in cancer cell death.
  • Imbalances in the cellular redox microenvironment are central to glioma pathology.

Conclusions:

  • The interplay between free radicals and antioxidant systems is crucial in glioma pathogenesis.
  • Targeting the redox microenvironment presents a promising avenue for developing novel glioma treatments.
  • Further research into redox modulation could enhance therapeutic strategies for brain tumors.
Keywords:
Gliomaantioxidant systemsapoptosisautophagyreactive oxygen species.

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