Identification of COL4A1 as a potential gene conferring trastuzumab resistance in gastric cancer based on

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Ru Huang1, Wenchao Gu1, Bin Sun2

  • 1Department of Heart Failure, Research Center for Translational Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, P.R. China.

Molecular Medicine Reports
|March 8, 2018
PubMed

Insights

Collagen type IV α1 chain (COL4A1) may cause trastuzumab resistance in gastric cancer. This study identified COL4A1 as a potential driver of resistance in HER2-overexpressing gastric cancer patients.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Trastuzumab is a targeted therapy for HER2-overexpressing gastric cancer.
  • Trastuzumab resistance is a significant clinical challenge, with mechanisms often unclear.

Purpose of the Study:

  • To investigate the role of collagen type IV α1 chain (COL4A1) in trastuzumab resistance in gastric cancer.
  • To identify potential molecular mechanisms underlying trastuzumab resistance.

Main Methods:

  • Bioinformatic analysis of two microarray datasets.
  • Protein/gene interaction and biological process annotation analyses.
  • Functional analysis of microRNAs targeting COL4A1 mRNA.

Main Results:

  • COL4A1 expression is upregulated in gastric cancer tissues and trastuzumab-resistant cells.
  • COL4A1 was identified as a potential inducer of trastuzumab resistance.
  • Validation confirmed COL4A1's role in conferring drug resistance.

Conclusions:

  • COL4A1 is a potential therapeutic target for overcoming trastuzumab resistance in gastric cancer.
  • Understanding COL4A1's function may lead to novel treatment strategies for resistant gastric cancer.
Keywords:
bioinformatics analysisgastric cancertrastuzumab resistancedifferentially expressed genescollagen type IV α1 chain

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