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Updated: Feb 13, 2026

In vitro Organoid Culture of Primary Mouse Colon Tumors
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In vitro Organoid Culture of Primary Mouse Colon Tumors

Published on: May 17, 2013

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Suppression of YAP by DDP disrupts colon tumor progression

Kun Li1, Jiwei Guo2, Yan Wu2

  • 1Department of Gastroenterology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, P.R. China.

Oncology Reports
|March 8, 2018
PubMed

Insights

Cisplatin (DDP) effectively suppresses the YAP oncogene in colon cancer, inhibiting tumor progression and metastasis. This study identifies DDP as a promising therapeutic agent targeting the Mst/Yap signaling pathway for colon cancer treatment.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Colon cancer often presents with poor prognosis and limited treatment efficacy due to drug resistance.
  • Activation of the YAP oncogene is linked to colon cancer progression, metastasis, and resistance to therapies.
  • Cisplatin (DDP) is a chemotherapy agent used for carcinomas, but its precise mechanisms, especially concerning YAP, are not fully understood.

Purpose of the Study:

  • To investigate whether Cisplatin (DDP) specifically suppresses YAP to inhibit colon cancer progression.
  • To elucidate the role of Mst/Yap signaling in colon cancer and its modulation by DDP.

Main Methods:

  • Analysis of Mst/Yap signaling activation in colon cancer tissues.
  • Assessment of DDP's effects on YAP expression at transcriptional and post-translational levels.
  • Evaluation of DDP's impact on cancer cell proliferation, apoptosis, senescence, epithelial-to-mesenchymal transition, and invasion.

Main Results:

  • Mst/Yap signaling is hyperactivated in colon cancers, promoting proliferation and invasion.
  • DDP treatment downregulates YAP expression, inducing cell cycle arrest, apoptosis, and senescence.
  • DDP inhibits epithelial-to-mesenchymal transition, reduces cell motility, invasion, and migration, while altering E-cadherin and vimentin expression.

Conclusions:

  • DDP effectively suppresses colon cancer progression by targeting the Mst/Yap signaling pathway.
  • DDP modulates YAP at both transcriptional and post-translational levels, influencing its subcellular localization.
  • DDP demonstrates potential as a therapeutic agent for colon cancer, specifically through YAP inhibition.

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