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Related Concept Videos

Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

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Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
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Rheumatic Heart Disease IV: Nursing Management01:20

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AssessmentA comprehensive assessment is essential in managing a patient with rheumatic heart disease (RHD). Begin with obtaining a detailed medical history, including recent streptococcal infections, a history of rheumatic fever, or previously diagnosed rheumatic heart disease. Assess the patient for symptoms such as fever, chest pain, widespread joint pain (arthralgia), tachycardia, pericardial friction rub, muffled heart sounds, heart murmurs, peripheral edema, subcutaneous nodules, and...
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Inflammatory Response01:28

Inflammatory Response

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An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
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Inflammatory Response II: Inflammatory Exudate and Tissue Repair01:24

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The immune system's inflammatory response destroys the invading pathogen, permitting the tissue to heal. The changes during the cellular and vascular stages allow exudate formation at the site of inflammation. The inflammatory exudate released from the wound has high protein content and a specific gravity above 1.020.
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Rheumatic Heart Disease III: Medical Management01:21

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Rheumatic heart disease (RHD) management can be divided into two main strategies: prevention and long-term management.Primary PreventionPrimary prevention focuses on timely diagnosis and management of group A streptococcal pharyngitis to prevent acute rheumatic fever. The most widely used antibiotic for treating this condition is intramuscular benzathine penicillin G.Acute Rheumatic Fever TreatmentThe primary treatment goal for a patient diagnosed with acute rheumatic fever is to suppress the...
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Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

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The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
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Investigating Alterations in Caecum Microbiota After Traumatic Brain Injury in Mice
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[Microbiota and inflammatory rheumatisms].

Matthias Jarlborg1, Deshiré Alpizar-Rodriguez1, Athan Baillet2

  • 1Service de rhumatologie, Département des spécialités de médecine, HUG, 1211 Genève 14.

Revue Medicale Suisse
|March 8, 2018
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Summary
This summary is machine-generated.

The gut bacterium Prevotella copri is more common in early rheumatoid arthritis (RA). Antibodies against this germ suggest it may trigger RA, alongside oral microbes linked to periodontitis.

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Area of Science:

  • Microbiology
  • Immunology
  • Rheumatology

Background:

  • The gut microbiota and dysbiosis are implicated in numerous diseases.
  • The influence of the microbiota on inflammatory rheumatisms is well-documented in mice and humans.

Purpose of the Study:

  • To investigate the role of specific bacteria, Prevotella copri, and oral microorganisms in the development and activity of rheumatoid arthritis (RA).

Main Methods:

  • Observational studies analyzing the prevalence of Prevotella copri in early RA patients.
  • Identification of specific antibodies against Prevotella copri in RA patients.
  • Association studies linking oral microorganisms from periodontitis to RA development and activity.

Main Results:

  • Prevotella copri, a Gram-negative intestinal bacterium, is found at higher prevalence in the early stages of RA.
  • Specific antibodies against Prevotella copri are identified in RA patients.
  • Oral microorganisms associated with periodontitis are linked to the development and activity of RA.

Conclusions:

  • Prevotella copri may play a role in the initiation of rheumatoid arthritis.
  • Oral microbiota, particularly those linked to periodontitis, are associated with RA.
  • These findings suggest novel therapeutic targets for managing inflammatory rheumatisms.