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Effects of fucoidan on diabetic rat testicular tissue

O Ersoy1, G Kizilay1

  • 1a Department of Histology and Embryology, Faculty of Medicine , Trakya University , Edirne , Turkey.

Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission
|March 8, 2018
PubMed

Insights

Early fucoidan treatment may protect against diabetes-induced testicular damage by reducing apoptosis and preserving sperm quality. This antioxidant shows promise in managing complications of diabetes.

Area of Science:

  • Reproductive biology
  • Endocrinology
  • Pharmacology

Background:

  • Diabetes mellitus leads to increased reactive oxygen species (ROS), causing oxidative stress and apoptosis.
  • This oxidative stress compromises sperm quality and testicular function.
  • Antioxidants like fucoidan may offer protective effects against diabetes-related complications.

Purpose of the Study:

  • To investigate the protective effects of fucoidan on testicular tissue in rats with experimentally induced diabetes.
  • To assess the impact of early versus late administration of fucoidan.

Main Methods:

  • Diabetes was induced in Wistar albino male rats using streptozotocin (STZ).
  • Rats were divided into control, diabetes, early fucoidan, and late fucoidan groups.
  • Fucoidan (50 mg/kg) was administered intraperitoneally every two days for four weeks.

Main Results:

  • Diabetic rats showed increased basement membrane thickness and apoptotic indices compared to controls.
  • Early fucoidan treatment (EFG) resulted in significantly greater seminiferous tubule diameters compared to the diabetic group (DG).
  • Both early and late fucoidan treatments significantly reduced apoptotic tubule and cell indices compared to the DG.

Conclusions:

  • Early administration of fucoidan may mitigate testicular damage caused by experimental diabetes.
  • Fucoidan's antioxidant properties appear to protect testicular tissues from ROS-induced apoptosis.
  • Fucoidan demonstrates potential therapeutic value in managing diabetic reproductive complications.
Keywords:
apoptosisdiabetesfucoidanratsreactive oxygen speciestestis

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