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Updated: Feb 13, 2026

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NOD2: Activation During Bacterial and Viral Infections, Polymorphisms and Potential as Therapeutic Target

Diana Alhelí Domínguez-Martínez1, Daniel Núñez-Avellaneda1, Carlos Alberto Castañón-Sánchez2

  • 1Laboratorio de Inmunología Celular e Inmunopatogénesis, Departamento de Inmunología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Mexico City, Mexico.

Revista De Investigacion Clinica; Organo Del Hospital De Enfermedades De La Nutricion
|March 8, 2018
PubMed

Insights

Nucleotide-binding domain (NBD) leucine-rich repeat (LRR)-containing receptors (NLRs), including NOD2, are crucial for detecting pathogens and maintaining tissue homeostasis. NOD2

Area of Science:

  • Immunology
  • Molecular Biology
  • Genetics

Background:

  • Nucleotide-binding domain (NBD) leucine-rich repeat (LRR)-containing receptors (NLRs) are cytoplasmic immune sensors.
  • NOD2, an NLR family member, dynamically interacts with proteins to modulate immune responses.
  • NOD2 plays roles in infection, tissue homeostasis, and inflammatory diseases.

Purpose of the Study:

  • To review the characteristics and importance of NOD2.
  • To discuss NOD2's role in bacterial and viral infections.
  • To examine NOD2's involvement in chronic inflammation and therapeutic potential.

Main Methods:

  • Literature review of experimental evidence and reports on NOD2.
  • Analysis of NOD2's interactions with effector proteins and other receptors.
  • Examination of NOD2 polymorphisms and their association with diseases.

Main Results:

  • NOD2 structural domains and effector protein interactions dictate anti-infective responses.
  • NOD2 is vital for immune responses against bacterial and viral pathogens.
  • NOD2 polymorphisms are linked to inflammatory diseases like Crohn's disease.

Conclusions:

  • NOD2 is a key regulator of innate immunity against infections.
  • NOD2's function extends to tissue homeostasis and inflammatory disease pathogenesis.
  • Targeting NOD2 presents potential therapeutic strategies for inflammatory conditions.
Keywords:
InfectionInflammasomeInflammatory diseaseNOD2Polymorphisms

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