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Related Concept Videos

Pharmaceutical Equivalents01:26

Pharmaceutical Equivalents

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As defined by regulatory standards, pharmaceutical equivalents require generic drug products to have identical dosage forms and chemically identical active pharmaceutical ingredients (APIs). They must adhere to compendial or applicable standards for potency, content uniformity, disintegration times, and dissolution rates. In the case of modified-release dosage forms, variations in drug content are permissible as long as the delivered amount remains consistent with the innovator drug product.
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Pharmaceutical Poisoning: Potential Scenarios01:26

Pharmaceutical Poisoning: Potential Scenarios

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Pharmaceutical poisoning can occur through various channels, impacting an estimated 2 million hospitalized patients in the U.S. annually with serious adverse drug responses. These scenarios encompass both therapeutic uses, such as drug toxicity, where even standard dosages can lead to severe central nervous system depression, and non-therapeutic exposures, including accidental ingestion by children, and environmental and occupational exposures.Unintentional poisonings often involve exploratory...
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Pharmaceutical Poisoning: Treatment Strategies01:26

Pharmaceutical Poisoning: Treatment Strategies

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Treatment strategies for poisoning are a critical aspect of emergency medicine, focusing on preventing the absorption of toxins and enhancing their elimination. When a poisoning incident occurs, the first response is to halt exposure and decontaminate the patient, particularly through gastrointestinal (GI) methods if the poison was ingested.Gastrointestinal Decontamination Techniques:Activated charcoal is the cornerstone of GI decontamination. It works through adsorption, binding the toxin to...
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Pharmaceutical Alternatives: Stability-Related Therapeutic Nonequivalence01:22

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Generic intravenous (IV) drugs are considered bioequivalent to their branded counterparts due to their 100% bioavailability upon administration. However, variations in stability among different drug products can significantly influence their therapeutic performance, even if they are pharmaceutically equivalent.Cefuroxime, a prophylactic antimicrobial, is often used as a single-dose IV injection for patients undergoing coronary artery bypass grafting surgery. A 3 g dose typically provides...
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Hybridoma Technology01:31

Hybridoma Technology

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Hybridoma technology is used for the large-scale production of monoclonal antibodies. Monoclonal antibodies bind to only a single antigenic determinant or epitope. Such antibodies are used in research, diagnostics, and disease therapy. The hybridoma technology established in 1975 by Georges Köhler and Cesar Milstein was awarded the Nobel Prize in Medicine in 1984 for revolutionizing research and therapy.
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Pharmaceutical Alternatives: Excipients and Impurities-Related Therapeutic Nonequivalence01:19

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Pharmaceutical products contain more than just the active drug; they also contain various excipients such as binders, solubilizers, stabilizers, preservatives, and other elements. In some cases, impurities or contaminants might be present. Traditionally, quality control in pharmaceuticals has primarily focused on the analysis of the active drug, often overlooking the impact of these additional components. The recent issue with heparin contamination by over-sulfated chondroitin sulfate, a...
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Fabrication of Engineered Vascular Flaps Using 3D Printing Technologies
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PRINTING TECHNIQUES: RECENT DEVELOPMENTS IN PHARMACEUTICAL TECHNOLOGY.

Witold Jamroz, Mateusz Kurek, Ewelina Lyszczarz

    Acta Poloniae Pharmaceutica
    |March 8, 2018
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    Summary

    Advancements in printing techniques, including 2D and 3D printing, are revolutionizing pharmaceutical technology and drug development. This review highlights recent achievements in printing medicines, showcasing their growing impact on the pharmaceutical industry.

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    Area of Science:

    • Pharmaceutical Technology
    • Drug Development
    • Advanced Manufacturing

    Background:

    • Significant progress has been made in printing techniques and their pharmaceutical applications.
    • The diverse range of printing methods necessitates systematization and explanation of their principles and uses.
    • The pharmaceutical industry is increasingly exploring 2D and 3D printing technologies.

    Purpose of the Study:

    • To review printing techniques employed in the drug development process.
    • To systematize various printing methods and explain their operational principles.
    • To detail the potential applications of printing technologies within pharmaceutical technology.

    Main Methods:

    • Literature review of scientific papers on printing techniques in pharmaceuticals.
    • Analysis of the principles of operation for different printing methods.
    • Examination of the latest research and achievements in printed medicines.

    Main Results:

    • A growing body of scientific literature demonstrates increasing interest in 2D and 3D printing.
    • The market introduction of the first printed drug (Spritam®) marks a significant milestone.
    • Researchers are achieving notable advancements in the field of printing medicines.

    Conclusions:

    • Printing techniques offer innovative solutions for pharmaceutical technology and drug development.
    • 3D printing, in particular, represents a transformative technology in medicine.
    • Continued research and development in printed medicines are expected to yield further breakthroughs.